Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists

Kyoungjin Shin; Jungwook Chin; Dongyup Hahn; Jaehwan Lee; Hoosang Hwang; Dong Hwan Won; Jungyeob Ham; Hyukjae Choi; Eunsoo Kang; Hiyoung Kim; Moon Kyeong Ju; Sang Jip Nam; Heonjoong Kang

doi:10.1016/j.steroids.2011.12.027

Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists

Kyoungjin Shin
, Jungwook Chin
, Dongyup Hahn
, Jaehwan Lee
, Hoosang Hwang
, Dong Hwan Won
, Jungyeob Ham
, Hyukjae Choi
, Eunsoo Kang
, Hiyoung Kim
, Moon Kyeong Ju
, Sang Jip Nam
, Heonjoong Kang

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC ₅₀'s 14 and 15 μM.

Original language	English
Pages (from-to)	355-359
Number of pages	5
Journal	Steroids
Volume	77
Issue number	5
DOIs	https://doi.org/10.1016/j.steroids.2011.12.027
State	Published - Apr 2012

Keywords

Cholestasis
Dendronephthya gigantea
Farnesoid X-activated receptor

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10.1016/j.steroids.2011.12.027

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@article{cb58ee6a502e40a3a47643ccefa363f5,

title = "Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists",

abstract = "Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC 50's 14 and 15 μM.",

keywords = "Cholestasis, Dendronephthya gigantea, Farnesoid X-activated receptor",

author = "Kyoungjin Shin and Jungwook Chin and Dongyup Hahn and Jaehwan Lee and Hoosang Hwang and Won, \{Dong Hwan\} and Jungyeob Ham and Hyukjae Choi and Eunsoo Kang and Hiyoung Kim and Ju, \{Moon Kyeong\} and Nam, \{Sang Jip\} and Heonjoong Kang",

year = "2012",

month = apr,

doi = "10.1016/j.steroids.2011.12.027",

language = "English",

volume = "77",

pages = "355--359",

journal = "Steroids",

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publisher = "Elsevier Inc.",

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AU - Lee, Jaehwan

AU - Hwang, Hoosang

AU - Won, Dong Hwan

AU - Ham, Jungyeob

AU - Choi, Hyukjae

AU - Kang, Eunsoo

AU - Kim, Hiyoung

AU - Ju, Moon Kyeong

AU - Nam, Sang Jip

AU - Kang, Heonjoong

PY - 2012/4

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AB - Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC 50's 14 and 15 μM.

KW - Cholestasis

KW - Dendronephthya gigantea

KW - Farnesoid X-activated receptor

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AN - SCOPUS:84862790074

SN - 0039-128X

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SP - 355

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JO - Steroids

JF - Steroids

IS - 5

ER -

Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists

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Keywords

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