Structural characterization and SARS-CoV-2 inhibitory effects of alkaloids from the roots of Asarum heterotropoides var. mandshuricum (Aristolochiaceae)

Thi Thanh Le, Thao Quyen Cao, Manh Tuan Ha, Kang Hyun Han, Yong Bum Kim, Jeong Ah Kim, Byung Sun Min

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Asarum heterotropoides var. mandshuricum F. Maekawa (Aristolochiaceae), well-known as “Marchurian Wildginger”, shows many bioactivities that contribute to its therapeutic effects against a wide range of diseases. In this study, phytochemical investigation of A. hetertotropoides var. mandshuricum root extract led to the isolation of one previously undescribed amide (asamide A) with a rare five-membered-ring acetonide group in natural sources and one new amide mixture (asamide B/C) together with fifteen known alkaloids and one known amide mixture. Structural elucidation of the new alkaloids was carried out based on conventional NMR spectroscopy, HRESI-MS, and ECD calculation. To the best of our knowledge, this is the first report on the isolation of asaroidoxazine B from A. heterotropoides var. mandshuricum and compounds N-feruloyl tyramine, trans-N-feruloyl octopamine, and N-trans-p-coumaroyltopamin from the genus Asarum. The isolated alkaloids were examined for their inhibitory effects on PDB6LU7 protein of SARS-CoV-2 by molecular docking. Accordingly, the isolated aristolactams, especially aristolactam glycosides were found to be promising agents for the research and development of the new anti-SARS-CoV-2 drugs.

Original languageEnglish
Pages (from-to)57-66
Number of pages10
JournalPhytochemistry Letters
Volume56
DOIs
StatePublished - Aug 2023

Keywords

  • Alkaloid
  • Aristolactam
  • Aristolochiaceae
  • Asarum heterotropoides
  • PDB6LU7 M
  • SARS-CoV-2

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