Styraxjaponoside a and b, antifungal lignan glycosides isolated from styrax japonica s. et z

Cana Park; Jaeyong Cho; Bomi Hwang; In Sok Hwang; Mi Ran Kim; Eun Rhan Woo; Dong Gun Lee

doi:10.4062/biomolther.2010.18.4.420

Styraxjaponoside a and b, antifungal lignan glycosides isolated from styrax japonica s. et z

Cana Park, Jaeyong Cho, Bomi Hwang, In Sok Hwang, Mi Ran Kim, Eun Rhan Woo, Dong Gun Lee

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The antifungal effects and action mechanisms of styraxjaponoside A and B were investigated. Devoid of hemolytic effect, the compounds had significant effect against several human pathogenic fungal strains, with energy-independent manners. To understand the action mechanisms of the compounds, the flow cytometric analysis plotting the forward scatter and the side scatter, DiBAC₄(3) staining and DPH fluorescence analysis were conducted. The results indicated that the actions of the compounds were dependent upon the membrane-active mechanisms. The present study suggests that styraxjaponoside A and B exert their antimicrobial effects via membrane-disruptive mechanisms.

Original language	English
Pages (from-to)	420-425
Number of pages	6
Journal	Biomolecules and Therapeutics
Volume	18
Issue number	4
DOIs	https://doi.org/10.4062/biomolther.2010.18.4.420
State	Published - 2010

Keywords

Antifungal activity
Lignans
Styrax japonica s. et z
Styraxjaponoside a
Styraxjaponoside b

Access to Document

10.4062/biomolther.2010.18.4.420

Cite this

@article{baf0308480d74f0ea08b44555c9c98f8,

title = "Styraxjaponoside a and b, antifungal lignan glycosides isolated from styrax japonica s. et z",

abstract = "The antifungal effects and action mechanisms of styraxjaponoside A and B were investigated. Devoid of hemolytic effect, the compounds had significant effect against several human pathogenic fungal strains, with energy-independent manners. To understand the action mechanisms of the compounds, the flow cytometric analysis plotting the forward scatter and the side scatter, DiBAC4(3) staining and DPH fluorescence analysis were conducted. The results indicated that the actions of the compounds were dependent upon the membrane-active mechanisms. The present study suggests that styraxjaponoside A and B exert their antimicrobial effects via membrane-disruptive mechanisms.",

keywords = "Antifungal activity, Lignans, Styrax japonica s. et z, Styraxjaponoside a, Styraxjaponoside b",

author = "Cana Park and Jaeyong Cho and Bomi Hwang and Hwang, {In Sok} and Kim, {Mi Ran} and Woo, {Eun Rhan} and Lee, {Dong Gun}",

year = "2010",

doi = "10.4062/biomolther.2010.18.4.420",

language = "English",

volume = "18",

pages = "420--425",

journal = "Biomolecules and Therapeutics",

issn = "1976-9148",

publisher = "Korean Society of Applied Pharmacology",

number = "4",

}

TY - JOUR

T1 - Styraxjaponoside a and b, antifungal lignan glycosides isolated from styrax japonica s. et z

AU - Park, Cana

AU - Cho, Jaeyong

AU - Hwang, Bomi

AU - Hwang, In Sok

AU - Kim, Mi Ran

AU - Woo, Eun Rhan

AU - Lee, Dong Gun

PY - 2010

Y1 - 2010

N2 - The antifungal effects and action mechanisms of styraxjaponoside A and B were investigated. Devoid of hemolytic effect, the compounds had significant effect against several human pathogenic fungal strains, with energy-independent manners. To understand the action mechanisms of the compounds, the flow cytometric analysis plotting the forward scatter and the side scatter, DiBAC4(3) staining and DPH fluorescence analysis were conducted. The results indicated that the actions of the compounds were dependent upon the membrane-active mechanisms. The present study suggests that styraxjaponoside A and B exert their antimicrobial effects via membrane-disruptive mechanisms.

AB - The antifungal effects and action mechanisms of styraxjaponoside A and B were investigated. Devoid of hemolytic effect, the compounds had significant effect against several human pathogenic fungal strains, with energy-independent manners. To understand the action mechanisms of the compounds, the flow cytometric analysis plotting the forward scatter and the side scatter, DiBAC4(3) staining and DPH fluorescence analysis were conducted. The results indicated that the actions of the compounds were dependent upon the membrane-active mechanisms. The present study suggests that styraxjaponoside A and B exert their antimicrobial effects via membrane-disruptive mechanisms.

KW - Antifungal activity

KW - Lignans

KW - Styrax japonica s. et z

KW - Styraxjaponoside a

KW - Styraxjaponoside b

UR - http://www.scopus.com/inward/record.url?scp=78449257443&partnerID=8YFLogxK

U2 - 10.4062/biomolther.2010.18.4.420

DO - 10.4062/biomolther.2010.18.4.420

M3 - Article

AN - SCOPUS:78449257443

SN - 1976-9148

VL - 18

SP - 420

EP - 425

JO - Biomolecules and Therapeutics

JF - Biomolecules and Therapeutics

IS - 4

ER -

Styraxjaponoside a and b, antifungal lignan glycosides isolated from styrax japonica s. et z

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this