Subacute (28 day) toxicity of surfactin C, a lipopeptide produced by Bacillus subtilis, in Rats

Youn Hwan Hwang; Myoung Seok Kim; In Bae Song; Byung Kwon Park; Jong Hwan Lim; Seung Chun Park; Hyo In Yun

doi:10.1248/jhs.55.351

Subacute (28 day) toxicity of surfactin C, a lipopeptide produced by Bacillus subtilis, in Rats

Youn Hwan Hwang, Myoung Seok Kim, In Bae Song, Byung Kwon Park, Jong Hwan Lim, Seung Chun Park, Hyo In Yun

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Surfactin C, produced by acillus subtilis isolated from Korean soybean paste, was given to Sprague-Dawley rats of both sexes at dose of 500, 1000 or 2000 mg/kg for 28 days. There were no surfactin C-related toxicities in survival, clinical signs, and hematological parameters in the experimental period. The highest dose of surfactin C showed the decrease in body weight gain despite normal food and water consumptions and the increase in relative liver weight. alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels were increased in animals administered with surfactin C of 1000 or 2000mg/kg. Zonal necrosis of hepatocyte around the hepatic vein was observed after administration of the same doses in a dose-dependent manner. In the present study, the no-observed-adverse-effect level (NOAEL) of surfactin C was 500 mg/kg following oral administration in rats.

Original language	English
Pages (from-to)	351-355
Number of pages	5
Journal	Journal of Health Science
Volume	55
Issue number	3
DOIs	https://doi.org/10.1248/jhs.55.351
State	Published - Jun 2009

Keywords

No-observed-adverse-effect level
Rats
Subacute toxicity
Surfactin C

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title = "Subacute (28 day) toxicity of surfactin C, a lipopeptide produced by Bacillus subtilis, in Rats",

abstract = "Surfactin C, produced by acillus subtilis isolated from Korean soybean paste, was given to Sprague-Dawley rats of both sexes at dose of 500, 1000 or 2000 mg/kg for 28 days. There were no surfactin C-related toxicities in survival, clinical signs, and hematological parameters in the experimental period. The highest dose of surfactin C showed the decrease in body weight gain despite normal food and water consumptions and the increase in relative liver weight. alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels were increased in animals administered with surfactin C of 1000 or 2000mg/kg. Zonal necrosis of hepatocyte around the hepatic vein was observed after administration of the same doses in a dose-dependent manner. In the present study, the no-observed-adverse-effect level (NOAEL) of surfactin C was 500 mg/kg following oral administration in rats.",

keywords = "No-observed-adverse-effect level, Rats, Subacute toxicity, Surfactin C",

author = "Hwang, \{Youn Hwan\} and Kim, \{Myoung Seok\} and Song, \{In Bae\} and Park, \{Byung Kwon\} and Lim, \{Jong Hwan\} and Park, \{Seung Chun\} and Yun, \{Hyo In\}",

year = "2009",

month = jun,

doi = "10.1248/jhs.55.351",

language = "English",

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pages = "351--355",

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issn = "1344-9702",

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T1 - Subacute (28 day) toxicity of surfactin C, a lipopeptide produced by Bacillus subtilis, in Rats

AU - Hwang, Youn Hwan

AU - Kim, Myoung Seok

AU - Song, In Bae

AU - Park, Byung Kwon

AU - Lim, Jong Hwan

AU - Park, Seung Chun

AU - Yun, Hyo In

PY - 2009/6

Y1 - 2009/6

N2 - Surfactin C, produced by acillus subtilis isolated from Korean soybean paste, was given to Sprague-Dawley rats of both sexes at dose of 500, 1000 or 2000 mg/kg for 28 days. There were no surfactin C-related toxicities in survival, clinical signs, and hematological parameters in the experimental period. The highest dose of surfactin C showed the decrease in body weight gain despite normal food and water consumptions and the increase in relative liver weight. alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels were increased in animals administered with surfactin C of 1000 or 2000mg/kg. Zonal necrosis of hepatocyte around the hepatic vein was observed after administration of the same doses in a dose-dependent manner. In the present study, the no-observed-adverse-effect level (NOAEL) of surfactin C was 500 mg/kg following oral administration in rats.

AB - Surfactin C, produced by acillus subtilis isolated from Korean soybean paste, was given to Sprague-Dawley rats of both sexes at dose of 500, 1000 or 2000 mg/kg for 28 days. There were no surfactin C-related toxicities in survival, clinical signs, and hematological parameters in the experimental period. The highest dose of surfactin C showed the decrease in body weight gain despite normal food and water consumptions and the increase in relative liver weight. alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels were increased in animals administered with surfactin C of 1000 or 2000mg/kg. Zonal necrosis of hepatocyte around the hepatic vein was observed after administration of the same doses in a dose-dependent manner. In the present study, the no-observed-adverse-effect level (NOAEL) of surfactin C was 500 mg/kg following oral administration in rats.

KW - No-observed-adverse-effect level

KW - Rats

KW - Subacute toxicity

KW - Surfactin C

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DO - 10.1248/jhs.55.351

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SN - 1344-9702

VL - 55

SP - 351

EP - 355

JO - Journal of Health Science

JF - Journal of Health Science

IS - 3

ER -

Subacute (28 day) toxicity of surfactin C, a lipopeptide produced by Bacillus subtilis, in Rats

Abstract

Keywords

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