Abstract
To evaluate as a scaffold for guided bone regeneration, the macroporous calcium metaphosphate ceramics, having 250μm or 450μm average pore size in an interconnected framework of structured blocks, were implanted into skid mice subcutaneous pouches for 3 weeks in a form of macroporous calcium metaphosphate ceramic-osteogenic cell complex. The macroporous calcium metaphosphate ceramics allowed appropriate cellular attachment and proliferation with osteogenic differentiation. In addition, the macroporous calcium metaphosphate ceramic-cell complex induced ectopic bone formation effectively along the inner surface of the interconnecting frame forming a macroporous structure. These findings suggest that macroporous calcium metaphosphate ceramic can be an ideal scaffolding material for guided bone regeneration in terms of an excellent delivery vehicle for osteogenic cells. Macroporous calcium metaphospate ceramic also possesses excellent biocompatibility, osteoconductivity, and controlled biodegradibility.
| Original language | English |
|---|---|
| Pages (from-to) | 631-634 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 254-256 |
| State | Published - 2004 |
| Event | The Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal Duration: 6 Nov 2003 → 9 Nov 2003 |
Keywords
- Ceramic-cell complex
- Macroporous calcium metaphosphate
- Osteoinduction
- Scaffold