Sulfatides Primarily Exist in the Substantia Nigra Region of Mouse Brain Tissue

Kab Tae Park; Jong Cheol Shon; Ji Eun Kim; Gyu Hwan Park; Hyun Jin Choi; Kwang Hyeon Liu

doi:10.1007/s11745-016-4224-z

Sulfatides Primarily Exist in the Substantia Nigra Region of Mouse Brain Tissue

Kab Tae Park, Jong Cheol Shon, Ji Eun Kim, Gyu Hwan Park, Hyun Jin Choi, Kwang Hyeon Liu

Research output: Contribution to journal › Article › peer-review

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Abstract

Lipid distribution in the brain is important for many biological functions and has been associated with some brain diseases. The aim of this study was to investigate lipid distribution in different regions of brain tissue in mice. To this end, substantia nigra (SN), caudate putamen (CPu), hippocampus (Hip), hypothalamus (Hyp), and cortex (Cx) tissues of mice were analyzed using direct infusion nanoelectrospray-ion trap mass spectrometry and multivariate analyses. The SN, CPu, Hip, Hyp, and Cx groups showed clear differences in lipid distribution using principal component analysis and a partial least-squares discriminant analysis score plot, and lipid levels were significantly different in different brain regions. In particular, sulfatides were mainly distributed in the SN region. Our results could be used to help understand the functions and mechanisms of lipids in various brain diseases.

Original language	English
Pages (from-to)	179-187
Number of pages	9
Journal	Lipids
Volume	52
Issue number	2
DOIs	https://doi.org/10.1007/s11745-016-4224-z
State	Published - 1 Feb 2017

Keywords

Brain regions
Direct infusion nanoelectrospray-ion trap mass spectrometry
Substantia nigra
Sulfatides

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10.1007/s11745-016-4224-z

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title = "Sulfatides Primarily Exist in the Substantia Nigra Region of Mouse Brain Tissue",

abstract = "Lipid distribution in the brain is important for many biological functions and has been associated with some brain diseases. The aim of this study was to investigate lipid distribution in different regions of brain tissue in mice. To this end, substantia nigra (SN), caudate putamen (CPu), hippocampus (Hip), hypothalamus (Hyp), and cortex (Cx) tissues of mice were analyzed using direct infusion nanoelectrospray-ion trap mass spectrometry and multivariate analyses. The SN, CPu, Hip, Hyp, and Cx groups showed clear differences in lipid distribution using principal component analysis and a partial least-squares discriminant analysis score plot, and lipid levels were significantly different in different brain regions. In particular, sulfatides were mainly distributed in the SN region. Our results could be used to help understand the functions and mechanisms of lipids in various brain diseases.",

keywords = "Brain regions, Direct infusion nanoelectrospray-ion trap mass spectrometry, Substantia nigra, Sulfatides",

author = "Park, {Kab Tae} and Shon, {Jong Cheol} and Kim, {Ji Eun} and Park, {Gyu Hwan} and Choi, {Hyun Jin} and Liu, {Kwang Hyeon}",

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doi = "10.1007/s11745-016-4224-z",

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T1 - Sulfatides Primarily Exist in the Substantia Nigra Region of Mouse Brain Tissue

AU - Park, Kab Tae

AU - Shon, Jong Cheol

AU - Kim, Ji Eun

AU - Park, Gyu Hwan

AU - Choi, Hyun Jin

AU - Liu, Kwang Hyeon

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Lipid distribution in the brain is important for many biological functions and has been associated with some brain diseases. The aim of this study was to investigate lipid distribution in different regions of brain tissue in mice. To this end, substantia nigra (SN), caudate putamen (CPu), hippocampus (Hip), hypothalamus (Hyp), and cortex (Cx) tissues of mice were analyzed using direct infusion nanoelectrospray-ion trap mass spectrometry and multivariate analyses. The SN, CPu, Hip, Hyp, and Cx groups showed clear differences in lipid distribution using principal component analysis and a partial least-squares discriminant analysis score plot, and lipid levels were significantly different in different brain regions. In particular, sulfatides were mainly distributed in the SN region. Our results could be used to help understand the functions and mechanisms of lipids in various brain diseases.

AB - Lipid distribution in the brain is important for many biological functions and has been associated with some brain diseases. The aim of this study was to investigate lipid distribution in different regions of brain tissue in mice. To this end, substantia nigra (SN), caudate putamen (CPu), hippocampus (Hip), hypothalamus (Hyp), and cortex (Cx) tissues of mice were analyzed using direct infusion nanoelectrospray-ion trap mass spectrometry and multivariate analyses. The SN, CPu, Hip, Hyp, and Cx groups showed clear differences in lipid distribution using principal component analysis and a partial least-squares discriminant analysis score plot, and lipid levels were significantly different in different brain regions. In particular, sulfatides were mainly distributed in the SN region. Our results could be used to help understand the functions and mechanisms of lipids in various brain diseases.

KW - Brain regions

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KW - Substantia nigra

KW - Sulfatides

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ER -

Sulfatides Primarily Exist in the Substantia Nigra Region of Mouse Brain Tissue

Abstract

Keywords

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