SUMOylation and Major Depressive Disorder

Seok Won Jeoung, Hyun Sun Park, Zae Young Ryoo, Dong Hyung Cho, Hyun Shik Lee, Hong Yeoul Ryu

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health. It has been discovered that neuronal dysfunction is a key factor in the development of major depressive disorder (MDD). PubMed and Google Scholar databases were searched with keywords such as ‘SUMO’, ‘neuronal plasticity’, and ‘depression’ to obtain relevant scientific literature. Here, we provide an overview of recent studies demonstrating the role of SUMOylation in maintaining neuronal function in participants suffering from MDD.

Original languageEnglish
Article number8023
JournalInternational Journal of Molecular Sciences
Volume23
Issue number14
DOIs
StatePublished - Jul 2022

Keywords

  • major depressive disorder (MDD)
  • mitochondria
  • neuron
  • SUMOylation
  • synapse

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