Suppressive effects of aloin on polyphosphate-mediated vascular inflammatory responses

In Chul Lee; Jong Sup Bae

doi:10.1080/10286020.2020.1724969

Suppressive effects of aloin on polyphosphate-mediated vascular inflammatory responses

In Chul Lee, Jong Sup Bae

Seowon University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Human endothelial cells-derived polyphosphate (PolyP) is one of the pro-inflammatory mediators as suggested by the previous reports. Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. Aloin inhibits PolyP-mediated barrier disruption, the expressions of cell adhesion molecules, and adhesion/migration of leukocyte to HUVEC. PolyP-induced NF-κB activation and the productions of TNF-α and IL-6 were inhibited by aloin in HUVECs. These anti-inflammatory functions of aloin were confirmed in PolyP-injected mice. In conclusion, based on the anti-inflammatory effects of aloin in PolyP-mediated septic response, aloin has therapeutic potential for various systemic inflammatory diseases.

Original language	English
Pages (from-to)	89-99
Number of pages	11
Journal	Journal of Asian Natural Products Research
Volume	23
Issue number	1
DOIs	https://doi.org/10.1080/10286020.2020.1724969
State	Published - 2021

Keywords

Aloin
barrier integrity
polyphosphate
vascular permeability

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10286020.2020.1724969

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title = "Suppressive effects of aloin on polyphosphate-mediated vascular inflammatory responses",

abstract = "Human endothelial cells-derived polyphosphate (PolyP) is one of the pro-inflammatory mediators as suggested by the previous reports. Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. Aloin inhibits PolyP-mediated barrier disruption, the expressions of cell adhesion molecules, and adhesion/migration of leukocyte to HUVEC. PolyP-induced NF-κB activation and the productions of TNF-α and IL-6 were inhibited by aloin in HUVECs. These anti-inflammatory functions of aloin were confirmed in PolyP-injected mice. In conclusion, based on the anti-inflammatory effects of aloin in PolyP-mediated septic response, aloin has therapeutic potential for various systemic inflammatory diseases.",

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T1 - Suppressive effects of aloin on polyphosphate-mediated vascular inflammatory responses

AU - Lee, In Chul

AU - Bae, Jong Sup

PY - 2021

Y1 - 2021

N2 - Human endothelial cells-derived polyphosphate (PolyP) is one of the pro-inflammatory mediators as suggested by the previous reports. Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. Aloin inhibits PolyP-mediated barrier disruption, the expressions of cell adhesion molecules, and adhesion/migration of leukocyte to HUVEC. PolyP-induced NF-κB activation and the productions of TNF-α and IL-6 were inhibited by aloin in HUVECs. These anti-inflammatory functions of aloin were confirmed in PolyP-injected mice. In conclusion, based on the anti-inflammatory effects of aloin in PolyP-mediated septic response, aloin has therapeutic potential for various systemic inflammatory diseases.

AB - Human endothelial cells-derived polyphosphate (PolyP) is one of the pro-inflammatory mediators as suggested by the previous reports. Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. Aloin inhibits PolyP-mediated barrier disruption, the expressions of cell adhesion molecules, and adhesion/migration of leukocyte to HUVEC. PolyP-induced NF-κB activation and the productions of TNF-α and IL-6 were inhibited by aloin in HUVECs. These anti-inflammatory functions of aloin were confirmed in PolyP-injected mice. In conclusion, based on the anti-inflammatory effects of aloin in PolyP-mediated septic response, aloin has therapeutic potential for various systemic inflammatory diseases.

KW - Aloin

KW - barrier integrity

KW - polyphosphate

KW - vascular permeability

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Suppressive effects of aloin on polyphosphate-mediated vascular inflammatory responses

Abstract

Keywords

UN SDGs

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