Surface coated Eu(OH)3 nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity

Krishna Kattel; Ja Young Park; Wenlong Xu; Badrul Alam Bony; Woo Cheol Heo; Tirusew Tegafaw; Cho Rong Kim; Md Wasi Ahmad; Seonguk Jin; Jong Su Baeck; Yongmin Chang; Tae Jeong Kim; Ji Eun Bae; Kwon Seok Chae; Ji Yun Jeong; Gang Ho Lee

doi:10.1166/jnn.2013.8081

Surface coated Eu(OH)₃ nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity

Krishna Kattel, Ja Young Park, Wenlong Xu, Badrul Alam Bony, Woo Cheol Heo, Tirusew Tegafaw, Cho Rong Kim, Md Wasi Ahmad, Seonguk Jin, Jong Su Baeck, Yongmin Chang, Tae Jeong Kim, Ji Eun Bae, Kwon Seok Chae, Ji Yun Jeong, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The water-soluble and biocompatible D-glucuronic acid coated Eu(OH) ₃ nanorods (average thickness x average length=9.0×118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at ∼600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)₃ nanorods are not toxic up to 100 μM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be ∼0.1 mM. Therefore, D-glucuronic acid coated Eu(OH) ₃ nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of ∼1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r₁ and r ₂ water proton relaxivities were estimated, implying that surface coated Eu(OH)₃ nanorods are not sufficient for MRI contrast agents.

Original language	English
Pages (from-to)	7214-7219
Number of pages	6
Journal	Journal of Nanoscience and Nanotechnology
Volume	13
Issue number	11
DOIs	https://doi.org/10.1166/jnn.2013.8081
State	Published - Nov 2013

Keywords

Cytotoxicity
Eu(OH) nanorod
Fluorescent properties
Water proton relaxivities.

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Kattel, K., Park, J. Y., Xu, W., Bony, B. A., Heo, W. C., Tegafaw, T., Kim, C. R., Ahmad, M. W., Jin, S., Baeck, J. S., Chang, Y., Kim, T. J., Bae, J. E., Chae, K. S., Jeong, J. Y., & Lee, G. H. (2013). Surface coated Eu(OH)₃ nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity. Journal of Nanoscience and Nanotechnology, 13(11), 7214-7219. https://doi.org/10.1166/jnn.2013.8081

@article{31c0d0e6231244778013562b4e05b70c,

title = "Surface coated Eu(OH)3 nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity",

abstract = "The water-soluble and biocompatible D-glucuronic acid coated Eu(OH) 3 nanorods (average thickness x average length=9.0×118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at ∼600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)3 nanorods are not toxic up to 100 μM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be ∼0.1 mM. Therefore, D-glucuronic acid coated Eu(OH) 3 nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of ∼1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r1 and r 2 water proton relaxivities were estimated, implying that surface coated Eu(OH)3 nanorods are not sufficient for MRI contrast agents.",

keywords = "Cytotoxicity, Eu(OH) nanorod, Fluorescent properties, Water proton relaxivities.",

author = "Krishna Kattel and Park, {Ja Young} and Wenlong Xu and Bony, {Badrul Alam} and Heo, {Woo Cheol} and Tirusew Tegafaw and Kim, {Cho Rong} and Ahmad, {Md Wasi} and Seonguk Jin and Baeck, {Jong Su} and Yongmin Chang and Kim, {Tae Jeong} and Bae, {Ji Eun} and Chae, {Kwon Seok} and Jeong, {Ji Yun} and Lee, {Gang Ho}",

year = "2013",

month = nov,

doi = "10.1166/jnn.2013.8081",

language = "English",

volume = "13",

pages = "7214--7219",

journal = "Journal of Nanoscience and Nanotechnology",

issn = "1533-4880",

publisher = "American Scientific Publishers",

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Kattel, K, Park, JY, Xu, W, Bony, BA, Heo, WC, Tegafaw, T, Kim, CR, Ahmad, MW, Jin, S, Baeck, JS, Chang, Y, Kim, TJ, Bae, JE, Chae, KS, Jeong, JY & Lee, GH 2013, 'Surface coated Eu(OH)₃ nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity', Journal of Nanoscience and Nanotechnology, vol. 13, no. 11, pp. 7214-7219. https://doi.org/10.1166/jnn.2013.8081

TY - JOUR

T1 - Surface coated Eu(OH)3 nanorods

T2 - A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity

AU - Kattel, Krishna

AU - Park, Ja Young

AU - Xu, Wenlong

AU - Bony, Badrul Alam

AU - Heo, Woo Cheol

AU - Tegafaw, Tirusew

AU - Kim, Cho Rong

AU - Ahmad, Md Wasi

AU - Jin, Seonguk

AU - Baeck, Jong Su

AU - Chang, Yongmin

AU - Kim, Tae Jeong

AU - Bae, Ji Eun

AU - Chae, Kwon Seok

AU - Jeong, Ji Yun

AU - Lee, Gang Ho

PY - 2013/11

Y1 - 2013/11

N2 - The water-soluble and biocompatible D-glucuronic acid coated Eu(OH) 3 nanorods (average thickness x average length=9.0×118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at ∼600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)3 nanorods are not toxic up to 100 μM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be ∼0.1 mM. Therefore, D-glucuronic acid coated Eu(OH) 3 nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of ∼1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r1 and r 2 water proton relaxivities were estimated, implying that surface coated Eu(OH)3 nanorods are not sufficient for MRI contrast agents.

AB - The water-soluble and biocompatible D-glucuronic acid coated Eu(OH) 3 nanorods (average thickness x average length=9.0×118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at ∼600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)3 nanorods are not toxic up to 100 μM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be ∼0.1 mM. Therefore, D-glucuronic acid coated Eu(OH) 3 nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of ∼1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r1 and r 2 water proton relaxivities were estimated, implying that surface coated Eu(OH)3 nanorods are not sufficient for MRI contrast agents.

KW - Cytotoxicity

KW - Eu(OH) nanorod

KW - Fluorescent properties

KW - Water proton relaxivities.

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U2 - 10.1166/jnn.2013.8081

DO - 10.1166/jnn.2013.8081

M3 - Article

C2 - 24245232

AN - SCOPUS:84891521011

SN - 1533-4880

VL - 13

SP - 7214

EP - 7219

JO - Journal of Nanoscience and Nanotechnology

JF - Journal of Nanoscience and Nanotechnology

IS - 11

ER -

Surface coated Eu(OH)₃ nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity

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Keywords

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