Surface coated Eu(OH)3 nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity

Krishna Kattel; Ja Young Park; Wenlong Xu; Badrul Alam Bony; Woo Cheol Heo; Tirusew Tegafaw; Cho Rong Kim; Md Wasi Ahmad; Seonguk Jin; Jong Su Baeck; Yongmin Chang; Tae Jeong Kim; Ji Eun Bae; Kwon Seok Chae; Ji Yun Jeong; Gang Ho Lee

doi:10.1166/jnn.2013.8081

Surface coated Eu(OH)₃ nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity

Krishna Kattel
, Ja Young Park
, Wenlong Xu
, Badrul Alam Bony
, Woo Cheol Heo
, Tirusew Tegafaw
, Cho Rong Kim
, Md Wasi Ahmad
, Seonguk Jin
, Jong Su Baeck
, Yongmin Chang
, Tae Jeong Kim
, Ji Eun Bae
, Kwon Seok Chae
, Ji Yun Jeong
, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The water-soluble and biocompatible D-glucuronic acid coated Eu(OH) ₃ nanorods (average thickness x average length=9.0×118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at ∼600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)₃ nanorods are not toxic up to 100 μM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be ∼0.1 mM. Therefore, D-glucuronic acid coated Eu(OH) ₃ nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of ∼1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r₁ and r ₂ water proton relaxivities were estimated, implying that surface coated Eu(OH)₃ nanorods are not sufficient for MRI contrast agents.

Original language	English
Pages (from-to)	7214-7219
Number of pages	6
Journal	Journal of Nanoscience and Nanotechnology
Volume	13
Issue number	11
DOIs	https://doi.org/10.1166/jnn.2013.8081
State	Published - Nov 2013

Keywords

Cytotoxicity
Eu(OH) nanorod
Fluorescent properties
Water proton relaxivities.

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Kattel, K., Park, J. Y., Xu, W., Bony, B. A., Heo, W. C., Tegafaw, T., Kim, C. R., Ahmad, M. W., Jin, S., Baeck, J. S., Chang, Y., Kim, T. J., Bae, J. E., Chae, K. S., Jeong, J. Y., & Lee, G. H. (2013). Surface coated Eu(OH)₃ nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity. Journal of Nanoscience and Nanotechnology, 13(11), 7214-7219. https://doi.org/10.1166/jnn.2013.8081

@article{31c0d0e6231244778013562b4e05b70c,

title = "Surface coated Eu(OH)3 nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity",

abstract = "The water-soluble and biocompatible D-glucuronic acid coated Eu(OH) 3 nanorods (average thickness x average length=9.0×118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at ∼600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)3 nanorods are not toxic up to 100 μM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be ∼0.1 mM. Therefore, D-glucuronic acid coated Eu(OH) 3 nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of ∼1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r1 and r 2 water proton relaxivities were estimated, implying that surface coated Eu(OH)3 nanorods are not sufficient for MRI contrast agents.",

keywords = "Cytotoxicity, Eu(OH) nanorod, Fluorescent properties, Water proton relaxivities.",

author = "Krishna Kattel and Park, \{Ja Young\} and Wenlong Xu and Bony, \{Badrul Alam\} and Heo, \{Woo Cheol\} and Tirusew Tegafaw and Kim, \{Cho Rong\} and Ahmad, \{Md Wasi\} and Seonguk Jin and Baeck, \{Jong Su\} and Yongmin Chang and Kim, \{Tae Jeong\} and Bae, \{Ji Eun\} and Chae, \{Kwon Seok\} and Jeong, \{Ji Yun\} and Lee, \{Gang Ho\}",

year = "2013",

month = nov,

doi = "10.1166/jnn.2013.8081",

language = "English",

volume = "13",

pages = "7214--7219",

journal = "Journal of Nanoscience and Nanotechnology",

issn = "1533-4880",

publisher = "American Scientific Publishers",

number = "11",

}

Kattel, K, Park, JY, Xu, W, Bony, BA, Heo, WC, Tegafaw, T, Kim, CR, Ahmad, MW, Jin, S, Baeck, JS, Chang, Y, Kim, TJ, Bae, JE, Chae, KS, Jeong, JY & Lee, GH 2013, 'Surface coated Eu(OH)₃ nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity', Journal of Nanoscience and Nanotechnology, vol. 13, no. 11, pp. 7214-7219. https://doi.org/10.1166/jnn.2013.8081

TY - JOUR

T1 - Surface coated Eu(OH)3 nanorods

T2 - A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity

AU - Kattel, Krishna

AU - Park, Ja Young

AU - Xu, Wenlong

AU - Bony, Badrul Alam

AU - Heo, Woo Cheol

AU - Tegafaw, Tirusew

AU - Kim, Cho Rong

AU - Ahmad, Md Wasi

AU - Jin, Seonguk

AU - Baeck, Jong Su

AU - Chang, Yongmin

AU - Kim, Tae Jeong

AU - Bae, Ji Eun

AU - Chae, Kwon Seok

AU - Jeong, Ji Yun

AU - Lee, Gang Ho

PY - 2013/11

Y1 - 2013/11

N2 - The water-soluble and biocompatible D-glucuronic acid coated Eu(OH) 3 nanorods (average thickness x average length=9.0×118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at ∼600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)3 nanorods are not toxic up to 100 μM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be ∼0.1 mM. Therefore, D-glucuronic acid coated Eu(OH) 3 nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of ∼1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r1 and r 2 water proton relaxivities were estimated, implying that surface coated Eu(OH)3 nanorods are not sufficient for MRI contrast agents.

AB - The water-soluble and biocompatible D-glucuronic acid coated Eu(OH) 3 nanorods (average thickness x average length=9.0×118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)3 nanorods showed a strong fluorescence at ∼600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)3 nanorods are not toxic up to 100 μM, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be ∼0.1 mM. Therefore, D-glucuronic acid coated Eu(OH) 3 nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of ∼1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r1 and r 2 water proton relaxivities were estimated, implying that surface coated Eu(OH)3 nanorods are not sufficient for MRI contrast agents.

KW - Cytotoxicity

KW - Eu(OH) nanorod

KW - Fluorescent properties

KW - Water proton relaxivities.

UR - https://www.scopus.com/pages/publications/84891521011

U2 - 10.1166/jnn.2013.8081

DO - 10.1166/jnn.2013.8081

M3 - Article

C2 - 24245232

AN - SCOPUS:84891521011

SN - 1533-4880

VL - 13

SP - 7214

EP - 7219

JO - Journal of Nanoscience and Nanotechnology

JF - Journal of Nanoscience and Nanotechnology

IS - 11

ER -

Surface coated Eu(OH)₃ nanorods: A facile synthesis, characterization, MR relaxivities and in vitro cytotoxicity

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Keywords

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