Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells

Mi Hyun Hwang; Zhi Qiang Chang; Eun Hee Kang; Jong Hwan Lim; Hyo In Yun; Man Hee Rhee; Kyu Shik Jeong; Seung Chun Park

doi:10.1007/s10529-007-9552-x

Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells

Mi Hyun Hwang, Zhi Qiang Chang, Eun Hee Kang, Jong Hwan Lim, Hyo In Yun, Man Hee Rhee, Kyu Shik Jeong, Seung Chun Park

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Intact pathogenic Mycoplasma hyopneumoniae at 100 μg protein ml ^-1 induced transcription of proinflammatory cytokines such as cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-α, interleukin(IL)-1, IL-6 and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. After pretreatment with 50 μg surfactin C/ml, purified from Bacillus subtilis, transcription of the COX-2, IL-1β, IL-6 and iNOS genes induced by M. hyopneumoniae was inhibited by 43%, 82%, 72% and 59%, respectively.

Original language	English
Pages (from-to)	229-233
Number of pages	5
Journal	Biotechnology Letters
Volume	30
Issue number	2
DOIs	https://doi.org/10.1007/s10529-007-9552-x
State	Published - Feb 2008

Keywords

Cyclooxygenase
Cytokine
Mycoplasma hyopneumoniae
Nitrite
Surfactin C

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10.1007/s10529-007-9552-x

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title = "Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells",

abstract = "Intact pathogenic Mycoplasma hyopneumoniae at 100 μg protein ml -1 induced transcription of proinflammatory cytokines such as cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-α, interleukin(IL)-1, IL-6 and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. After pretreatment with 50 μg surfactin C/ml, purified from Bacillus subtilis, transcription of the COX-2, IL-1β, IL-6 and iNOS genes induced by M. hyopneumoniae was inhibited by 43%, 82%, 72% and 59%, respectively.",

keywords = "Cyclooxygenase, Cytokine, Mycoplasma hyopneumoniae, Nitrite, Surfactin C",

author = "Hwang, {Mi Hyun} and Chang, {Zhi Qiang} and Kang, {Eun Hee} and Lim, {Jong Hwan} and Yun, {Hyo In} and Rhee, {Man Hee} and Jeong, {Kyu Shik} and Park, {Seung Chun}",

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T1 - Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells

AU - Hwang, Mi Hyun

AU - Chang, Zhi Qiang

AU - Kang, Eun Hee

AU - Lim, Jong Hwan

AU - Yun, Hyo In

AU - Rhee, Man Hee

AU - Jeong, Kyu Shik

AU - Park, Seung Chun

PY - 2008/2

Y1 - 2008/2

N2 - Intact pathogenic Mycoplasma hyopneumoniae at 100 μg protein ml -1 induced transcription of proinflammatory cytokines such as cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-α, interleukin(IL)-1, IL-6 and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. After pretreatment with 50 μg surfactin C/ml, purified from Bacillus subtilis, transcription of the COX-2, IL-1β, IL-6 and iNOS genes induced by M. hyopneumoniae was inhibited by 43%, 82%, 72% and 59%, respectively.

AB - Intact pathogenic Mycoplasma hyopneumoniae at 100 μg protein ml -1 induced transcription of proinflammatory cytokines such as cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-α, interleukin(IL)-1, IL-6 and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. After pretreatment with 50 μg surfactin C/ml, purified from Bacillus subtilis, transcription of the COX-2, IL-1β, IL-6 and iNOS genes induced by M. hyopneumoniae was inhibited by 43%, 82%, 72% and 59%, respectively.

KW - Cyclooxygenase

KW - Cytokine

KW - Mycoplasma hyopneumoniae

KW - Nitrite

KW - Surfactin C

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JO - Biotechnology Letters

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ER -

Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells

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