Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

Mi Hyun Hwang; Jong Hwan Lim; Hyo In Yun; Man Hee Rhee; Jae Youl Cho; Walter H. Hsu; Seung Chun Park

doi:10.1007/s10529-005-2515-1

Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

Mi Hyun Hwang, Jong Hwan Lim, Hyo In Yun, Man Hee Rhee, Jae Youl Cho, Walter H. Hsu, Seung Chun Park

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 μg ml ^-1)-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 μg ml^-1 inhibited the LPS-induced increase in the transcription of IL-1β and iNOS and nitric oxide (NO) production in a dose-dependent manner.

Original language	English
Pages (from-to)	1605-1608
Number of pages	4
Journal	Biotechnology Letters
Volume	27
Issue number	20
DOIs	https://doi.org/10.1007/s10529-005-2515-1
State	Published - Oct 2005

Keywords

Cyclooxygenase
Cytokine
Interleukin-1β
Nitric oxide
Surfactin

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10.1007/s10529-005-2515-1

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title = "Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells",

abstract = "The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 μg ml -1)-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 μg ml-1 inhibited the LPS-induced increase in the transcription of IL-1β and iNOS and nitric oxide (NO) production in a dose-dependent manner.",

keywords = "Cyclooxygenase, Cytokine, Interleukin-1β, Nitric oxide, Surfactin",

author = "Hwang, {Mi Hyun} and Lim, {Jong Hwan} and Yun, {Hyo In} and Rhee, {Man Hee} and Cho, {Jae Youl} and Hsu, {Walter H.} and Park, {Seung Chun}",

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T1 - Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

AU - Hwang, Mi Hyun

AU - Lim, Jong Hwan

AU - Yun, Hyo In

AU - Rhee, Man Hee

AU - Cho, Jae Youl

AU - Hsu, Walter H.

AU - Park, Seung Chun

PY - 2005/10

Y1 - 2005/10

N2 - The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 μg ml -1)-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 μg ml-1 inhibited the LPS-induced increase in the transcription of IL-1β and iNOS and nitric oxide (NO) production in a dose-dependent manner.

AB - The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 μg ml -1)-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 μg ml-1 inhibited the LPS-induced increase in the transcription of IL-1β and iNOS and nitric oxide (NO) production in a dose-dependent manner.

KW - Cyclooxygenase

KW - Cytokine

KW - Interleukin-1β

KW - Nitric oxide

KW - Surfactin

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AN - SCOPUS:27144524870

SN - 0141-5492

VL - 27

SP - 1605

EP - 1608

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 20

ER -

Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

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