TY - JOUR
T1 - Synergistic effect of ROS-generating polydopamine on drug-induced bone tissue regeneration
AU - Han, Hyeju
AU - Kang, Bongkyun
AU - Sharker, Shazid Md
AU - Kashem, Tabassum Binte
AU - Kim, Yuejin
AU - Lee, Jeehee
AU - Park, Minok
AU - Kim, Eunjeong
AU - Jung, Yun Jae
AU - Lim, Jinkyu
AU - Ryu, Seungwon
AU - Lee, Kyueui
N1 - Publisher Copyright:
© 2024 The Royal Society of Chemistry.
PY - 2024/10/10
Y1 - 2024/10/10
N2 - A PHD (prolyl hydroxylase) inhibitor, 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA), is a drug that can artificially promote tissue regeneration by enhancing metabolic activity through the upregulation of hypoxia inducible factor 1 subunit alpha (Hif-1α) under normoxic conditions. This study presents a novel design methodology for a drug delivery system to maximize the regenerative effect of 1,4-DPCA. Specifically, by encapsulating 1,4-DPCA in polydopamine (PDA) that generates reactive oxygen species (ROS), the combined effects of Hif-1α upregulation and the induction of cellular antioxidant defense mechanisms by localized ROS can significantly enhance tissue regeneration. The study confirmed that each material (PDA and 1,4-DPCA) triggers a positive synergistic effect on the regenerative mechanisms. As a result, the use of a PDA drug delivery system loaded with 1,4-DPCA showed approximately six times greater bone regeneration compared to the control (no treatment) in a mouse calvarial defect model.
AB - A PHD (prolyl hydroxylase) inhibitor, 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA), is a drug that can artificially promote tissue regeneration by enhancing metabolic activity through the upregulation of hypoxia inducible factor 1 subunit alpha (Hif-1α) under normoxic conditions. This study presents a novel design methodology for a drug delivery system to maximize the regenerative effect of 1,4-DPCA. Specifically, by encapsulating 1,4-DPCA in polydopamine (PDA) that generates reactive oxygen species (ROS), the combined effects of Hif-1α upregulation and the induction of cellular antioxidant defense mechanisms by localized ROS can significantly enhance tissue regeneration. The study confirmed that each material (PDA and 1,4-DPCA) triggers a positive synergistic effect on the regenerative mechanisms. As a result, the use of a PDA drug delivery system loaded with 1,4-DPCA showed approximately six times greater bone regeneration compared to the control (no treatment) in a mouse calvarial defect model.
UR - https://www.scopus.com/pages/publications/85206524465
U2 - 10.1039/d4nr02887b
DO - 10.1039/d4nr02887b
M3 - Article
C2 - 39405040
AN - SCOPUS:85206524465
SN - 2040-3364
VL - 16
SP - 20118
EP - 20130
JO - Nanoscale
JF - Nanoscale
IS - 43
ER -