Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids

Dongguk Min; Minkyu Kim; Jéŕemy Ricci; Sora Jung; Kirim Kim; Won Yoon Chung; Kwang Kyun Park; Mankil Jung

doi:10.1248/cpb.c14-00036

Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids

Dongguk Min
, Minkyu Kim
, Jéŕemy Ricci
, Sora Jung
, Kirim Kim
, Won Yoon Chung
, Kwang Kyun Park
, Mankil Jung

Department of Dental Hygiene

Yonsei University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin- glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.

Original language	English
Pages (from-to)	446-453
Number of pages	8
Journal	Chemical and Pharmaceutical Bulletin
Volume	62
Issue number	5
DOIs	https://doi.org/10.1248/cpb.c14-00036
State	Published - May 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer activity
Deoxoartemisinin
Glycolipid hybrid
Oral squamous carcinoma

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10.1248/cpb.c14-00036

Cite this

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title = "Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids",

abstract = "The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin- glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.",

keywords = "Anticancer activity, Deoxoartemisinin, Glycolipid hybrid, Oral squamous carcinoma",

author = "Dongguk Min and Minkyu Kim and J{\'e}{\'r}emy Ricci and Sora Jung and Kirim Kim and Chung, \{Won Yoon\} and Park, \{Kwang Kyun\} and Mankil Jung",

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language = "English",

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AU - Min, Dongguk

AU - Kim, Minkyu

AU - Ricci, Jéŕemy

AU - Jung, Sora

AU - Kim, Kirim

AU - Chung, Won Yoon

AU - Park, Kwang Kyun

AU - Jung, Mankil

PY - 2014/5

Y1 - 2014/5

N2 - The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin- glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.

AB - The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin- glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.

KW - Anticancer activity

KW - Deoxoartemisinin

KW - Glycolipid hybrid

KW - Oral squamous carcinoma

UR - https://www.scopus.com/pages/publications/84899725187

U2 - 10.1248/cpb.c14-00036

DO - 10.1248/cpb.c14-00036

M3 - Article

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AN - SCOPUS:84899725187

SN - 0009-2363

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EP - 453

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 5

ER -

Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids

Abstract

UN SDGs

Keywords

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