Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents

Dae Seop Shin, Jiin Kim, Dong Cho Han, Kwang Hee Son, Chang Woo Lee, Hwan Mook Kim, Su Hyung Hong, Byoung Mog Kwon

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.

Original languageEnglish
Pages (from-to)5423-5427
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number19
DOIs
StatePublished - 1 Oct 2007

Keywords

  • Apoptosis
  • Cell cycle
  • Cinnamaldehyde

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