Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents

Dae Seop Shin; Jiin Kim; Dong Cho Han; Kwang Hee Son; Chang Woo Lee; Hwan Mook Kim; Su Hyung Hong; Byoung Mog Kwon

doi:10.1016/j.bmcl.2007.07.033

Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents

Dae Seop Shin
, Jiin Kim
, Dong Cho Han
, Kwang Hee Son
, Chang Woo Lee
, Hwan Mook Kim
, Su Hyung Hong
, Byoung Mog Kwon

Department of Dentistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G₂/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.

Original language	English
Pages (from-to)	5423-5427
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2007.07.033
State	Published - 1 Oct 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Cell cycle
Cinnamaldehyde

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10.1016/j.bmcl.2007.07.033

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title = "Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents",

abstract = "A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.",

keywords = "Apoptosis, Cell cycle, Cinnamaldehyde",

author = "Shin, \{Dae Seop\} and Jiin Kim and Han, \{Dong Cho\} and Son, \{Kwang Hee\} and Lee, \{Chang Woo\} and Kim, \{Hwan Mook\} and Hong, \{Su Hyung\} and Kwon, \{Byoung Mog\}",

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doi = "10.1016/j.bmcl.2007.07.033",

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TY - JOUR

T1 - Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents

AU - Shin, Dae Seop

AU - Kim, Jiin

AU - Han, Dong Cho

AU - Son, Kwang Hee

AU - Lee, Chang Woo

AU - Kim, Hwan Mook

AU - Hong, Su Hyung

AU - Kwon, Byoung Mog

PY - 2007/10/1

Y1 - 2007/10/1

N2 - A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.

AB - A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.

KW - Apoptosis

KW - Cell cycle

KW - Cinnamaldehyde

UR - https://www.scopus.com/pages/publications/34548546377

U2 - 10.1016/j.bmcl.2007.07.033

DO - 10.1016/j.bmcl.2007.07.033

M3 - Article

C2 - 17683933

AN - SCOPUS:34548546377

SN - 0960-894X

VL - 17

SP - 5423

EP - 5427

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents

Abstract

UN SDGs

Keywords

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