Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

Byeoung Soo Park; Dae Young Kim; Philip J. Rosenthal; Sun Chul Huh; Belinda J. Lee; Eun Ju Park; Sung Min Kim; Jang Eok Kim; Mi Hee Kim; Tae Lin Huh; Young Jae Choi; Ki Hyung Suh; Won Sik Choi; Sung Eun Lee

doi:10.1016/S0960-894X(02)00173-7

Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

Byeoung Soo Park, Dae Young Kim, Philip J. Rosenthal, Sun Chul Huh, Belinda J. Lee, Eun Ju Park, Sung Min Kim, Jang Eok Kim, Mi Hee Kim, Tae Lin Huh, Young Jae Choi, Ki Hyung Suh, Won Sik Choi, Sung Eun Lee

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Abstract

In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.

Original language	English
Pages (from-to)	1351-1355
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(02)00173-7
State	Published - 20 May 2002

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Park, B. S., Kim, D. Y., Rosenthal, P. J., Huh, S. C., Lee, B. J., Park, E. J., Kim, S. M., Kim, J. E., Kim, M. H., Huh, T. L., Choi, Y. J., Suh, K. H., Choi, W. S., & Lee, S. E. (2002). Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen. Bioorganic and Medicinal Chemistry Letters, 12(10), 1351-1355. https://doi.org/10.1016/S0960-894X(02)00173-7

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title = "Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen",

abstract = "In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.",

author = "Park, {Byeoung Soo} and Kim, {Dae Young} and Rosenthal, {Philip J.} and Huh, {Sun Chul} and Lee, {Belinda J.} and Park, {Eun Ju} and Kim, {Sung Min} and Kim, {Jang Eok} and Kim, {Mi Hee} and Huh, {Tae Lin} and Choi, {Young Jae} and Suh, {Ki Hyung} and Choi, {Won Sik} and Lee, {Sung Eun}",

year = "2002",

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doi = "10.1016/S0960-894X(02)00173-7",

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Park, BS, Kim, DY, Rosenthal, PJ, Huh, SC, Lee, BJ, Park, EJ, Kim, SM, Kim, JE, Kim, MH, Huh, TL, Choi, YJ, Suh, KH, Choi, WS & Lee, SE 2002, 'Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 10, pp. 1351-1355. https://doi.org/10.1016/S0960-894X(02)00173-7

TY - JOUR

T1 - Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

AU - Park, Byeoung Soo

AU - Kim, Dae Young

AU - Rosenthal, Philip J.

AU - Huh, Sun Chul

AU - Lee, Belinda J.

AU - Park, Eun Ju

AU - Kim, Sung Min

AU - Kim, Jang Eok

AU - Kim, Mi Hee

AU - Huh, Tae Lin

AU - Choi, Young Jae

AU - Suh, Ki Hyung

AU - Choi, Won Sik

AU - Lee, Sung Eun

PY - 2002/5/20

Y1 - 2002/5/20

N2 - In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.

AB - In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.

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U2 - 10.1016/S0960-894X(02)00173-7

DO - 10.1016/S0960-894X(02)00173-7

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AN - SCOPUS:0037140882

SN - 0960-894X

VL - 12

SP - 1351

EP - 1355

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

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