Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

Byeoung Soo Park; Dae Young Kim; Philip J. Rosenthal; Sun Chul Huh; Belinda J. Lee; Eun Ju Park; Sung Min Kim; Jang Eok Kim; Mi Hee Kim; Tae Lin Huh; Young Jae Choi; Ki Hyung Suh; Won Sik Choi; Sung Eun Lee

doi:10.1016/S0960-894X(02)00173-7

Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

Byeoung Soo Park
, Dae Young Kim
, Philip J. Rosenthal
, Sun Chul Huh
, Belinda J. Lee
, Eun Ju Park
, Sung Min Kim
, Jang Eok Kim
, Mi Hee Kim
, Tae Lin Huh
, Young Jae Choi
, Ki Hyung Suh
, Won Sik Choi
, Sung Eun Lee

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.

Original language	English
Pages (from-to)	1351-1355
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(02)00173-7
State	Published - 20 May 2002

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Park, B. S., Kim, D. Y., Rosenthal, P. J., Huh, S. C., Lee, B. J., Park, E. J., Kim, S. M., Kim, J. E., Kim, M. H., Huh, T. L., Choi, Y. J., Suh, K. H., Choi, W. S., & Lee, S. E. (2002). Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen. Bioorganic and Medicinal Chemistry Letters, 12(10), 1351-1355. https://doi.org/10.1016/S0960-894X(02)00173-7

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title = "Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen",

abstract = "In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.",

author = "Park, \{Byeoung Soo\} and Kim, \{Dae Young\} and Rosenthal, \{Philip J.\} and Huh, \{Sun Chul\} and Lee, \{Belinda J.\} and Park, \{Eun Ju\} and Kim, \{Sung Min\} and Kim, \{Jang Eok\} and Kim, \{Mi Hee\} and Huh, \{Tae Lin\} and Choi, \{Young Jae\} and Suh, \{Ki Hyung\} and Choi, \{Won Sik\} and Lee, \{Sung Eun\}",

year = "2002",

month = may,

day = "20",

doi = "10.1016/S0960-894X(02)00173-7",

language = "English",

volume = "12",

pages = "1351--1355",

journal = "Bioorganic and Medicinal Chemistry Letters",

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Park, BS, Kim, DY, Rosenthal, PJ, Huh, SC, Lee, BJ, Park, EJ, Kim, SM, Kim, JE, Kim, MH, Huh, TL, Choi, YJ, Suh, KH, Choi, WS & Lee, SE 2002, 'Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 10, pp. 1351-1355. https://doi.org/10.1016/S0960-894X(02)00173-7

TY - JOUR

T1 - Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

AU - Park, Byeoung Soo

AU - Kim, Dae Young

AU - Rosenthal, Philip J.

AU - Huh, Sun Chul

AU - Lee, Belinda J.

AU - Park, Eun Ju

AU - Kim, Sung Min

AU - Kim, Jang Eok

AU - Kim, Mi Hee

AU - Huh, Tae Lin

AU - Choi, Young Jae

AU - Suh, Ki Hyung

AU - Choi, Won Sik

AU - Lee, Sung Eun

PY - 2002/5/20

Y1 - 2002/5/20

N2 - In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.

AB - In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.

UR - https://www.scopus.com/pages/publications/0037140882

U2 - 10.1016/S0960-894X(02)00173-7

DO - 10.1016/S0960-894X(02)00173-7

M3 - Article

C2 - 11992775

AN - SCOPUS:0037140882

SN - 0960-894X

VL - 12

SP - 1351

EP - 1355

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

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