Synthesis, characterization, and anticancer activity of benzothiazole aniline derivatives and their platinum (Ii) complexes as new chemotherapy agents

Md Kamrul Islam, Ah Rum Baek, Bokyung Sung, Byeong Woo Yang, Garam Choi, Hyun Jin Park, Yeoun Hee Kim, Minsup Kim, Seongmin Ha, Gang Ho Lee, Hee Kyung Kim, Yongmin Chang

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21 Scopus citations

Abstract

We describe the synthesis, characterization, molecular modeling, and in vitro anticancer activity of three benzothiazole aniline (BTA) ligands and their corresponding platinum (II) complexes. We designed the compounds based on the selective antitumor properties of BTA, along with three types of metallic centers, aiming to take advantage of the distinctive and synergistic activity of the complexes to develop anticancer agents. The compounds were characterized using nuclear magnetic resonance spectrometry, Fourier transform infrared spectroscopy, mass spectrometry, elemental analysis, and tested for antiproliferative activity against multiple normal and cancerous cell lines. L1, L2, and L1Pt had better cytotoxicity in the liver, breast, lung, prostate, kidney, and brain cells than clinically used cisplatin. Especially, L1 and L1Pt demonstrated selective inhibitory activities against liver cancer cells. Therefore, these compounds can be a promising alternative to the present chemotherapy drugs.

Original languageEnglish
Article number832
JournalPharmaceuticals
Volume14
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • Anticancer
  • Benzothiazole aniline (BTA)
  • DNA
  • Docking
  • Liver
  • Platinum (II)

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