Synthesis, Characterization, and Enhanced Cancer-Imaging Application of Trans-activator of Transcription Peptide-conjugated Ultrasmall Gadolinium Oxide Nanoparticles

Mohammad Yaseen Ahmad, Hyunsil Cha, In Taek Oh, Tirusew Tegafaw, Xu Miao, Son Long Ho, Shanti Marasini, Adibehalsadat Ghazanfari, Huan Yue, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We prepared gadolinium oxide (Gd2O3) nanoparticles (GNPs) coated with a trans-activator of transcription (TAT) peptide with cell-penetrating ability (i.e., TAT-GNPs) through one-pot process. We characterized the particle diameter, surface-coating structure, water proton relaxivities, and in vitro cellular toxicities of the TAT-GNPs. We measured in vivo T1 magnetic resonance images (MRI) in a model nude mouse with liver cancer prior and posterior to intravenous administration. The average particle diameter of the GNPs was 1.5 nm. The sample solution exhibited a longitudinal water proton relaxivity (r1) of 18.2/s/mM (r2/r1 = 1.6, r2 = transverse water proton relaxivity), which is four to five times higher than those of commercial Gd-chelates. The in vivo T1 MRI exhibited positively (or T1) enhanced contrasts in the mouse liver cancer after intravenous administration, demonstrating that the TAT-GNPs acted as an enhanced cancer-imaging agent similar to the cancer-targeting agent in T1 MRI.

Original languageEnglish
Pages (from-to)435-441
Number of pages7
JournalBulletin of the Korean Chemical Society
Volume39
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • Enhanced cancer imaging
  • T magnetic resonance imaging
  • Trans-activator of transcription peptide
  • Trans-activator of transcription-gadolinium oxide nanoparticles
  • Ultrasmall gadolinium oxide nanoparticles

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