TY - JOUR
T1 - Synthesis, characterization, DNA binding and cleavage studies of Ru(II) complexes containing oxime ligands
AU - Chitrapriya, Nataraj
AU - Mahalingam, Viswanathan
AU - Zeller, Matthias
AU - Lee, Hyosun
AU - Natarajan, Karuppannan
PY - 2010/12/15
Y1 - 2010/12/15
N2 - The Ru(II) precursors, [RuHCl(CO)(EPh3)3] (E = P or As) when reacted with some well known monoxime and dioxime ligands in ethanolic solution afforded the new complexes of the types [RuCl(CO)(EPh3) 2L1], [RuH(CO)(EPh3)2L2] and [RuCl(CO)(EPh 3)2L3] ((H1L1) = diacetylmonoxime, (H 1L2) = dimethylglyoxime and (H2L3) = benzoiloxime). The ligands coordinated in a bidentate chelate mode forming a five membered chelate ring. The molecular structures of two of the complexes have been determined by single crystal X-ray diffraction study. The structural determination confirms the deprotonation of the oxime function. Examination of all the complexes by cyclic voltammetry showed the occurrence of some quasi-reversible redox reactions owing to changes in the oxidation state of the central metal atoms. Structural assignments are supported by combination of IR, UV-Vis, 1H NMR and elemental analyses. In addition, the DNA binding properties and cleavage efficiency of new complexes have been tested.
AB - The Ru(II) precursors, [RuHCl(CO)(EPh3)3] (E = P or As) when reacted with some well known monoxime and dioxime ligands in ethanolic solution afforded the new complexes of the types [RuCl(CO)(EPh3) 2L1], [RuH(CO)(EPh3)2L2] and [RuCl(CO)(EPh 3)2L3] ((H1L1) = diacetylmonoxime, (H 1L2) = dimethylglyoxime and (H2L3) = benzoiloxime). The ligands coordinated in a bidentate chelate mode forming a five membered chelate ring. The molecular structures of two of the complexes have been determined by single crystal X-ray diffraction study. The structural determination confirms the deprotonation of the oxime function. Examination of all the complexes by cyclic voltammetry showed the occurrence of some quasi-reversible redox reactions owing to changes in the oxidation state of the central metal atoms. Structural assignments are supported by combination of IR, UV-Vis, 1H NMR and elemental analyses. In addition, the DNA binding properties and cleavage efficiency of new complexes have been tested.
KW - DNA binding and cleavage
KW - Electrochemistry
KW - Oximato oxygen
KW - Ru(II) oxime complexes
KW - X-ray crystal structures
UR - http://www.scopus.com/inward/record.url?scp=78649326294&partnerID=8YFLogxK
U2 - 10.1016/j.molstruc.2010.09.004
DO - 10.1016/j.molstruc.2010.09.004
M3 - Article
AN - SCOPUS:78649326294
SN - 0022-2860
VL - 984
SP - 30
EP - 38
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
IS - 1-3
ER -