Synthesis, characterizations, and 9.4 tesla t2 mr images of polyacrylic acid‐coated terbium(iii) and holmium(iii) oxide nanoparticles

Shanti Marasini; Huan Yue; Son Long Ho; Ji Ae Park; Soyeon Kim; Ki Hye Jung; Hyunsil Cha; Shuwen Liu; Tirusew Tegafaw; Mohammad Yaseen Ahmad; Adibehalsadat Ghazanfari; Kwon Seok Chae; Yongmin Chang; Gang Ho Lee

doi:10.3390/nano11051355

Synthesis, characterizations, and 9.4 tesla t2 mr images of polyacrylic acid‐coated terbium(iii) and holmium(iii) oxide nanoparticles

Shanti Marasini, Huan Yue, Son Long Ho, Ji Ae Park, Soyeon Kim, Ki Hye Jung, Hyunsil Cha, Shuwen Liu, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Adibehalsadat Ghazanfari, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee

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Abstract

Polyacrylic acid (PAA)‐coated lanthanide oxide (Ln2O3) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T2) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r2 values were appreciable at a 3.0 T MR field and higher at a 9.4 T MR field, whereas their r1 values were negligible at all MR fields, indicating their exclusive induction of T2 relaxations with negligible induction of T1 relaxations. Their effectiveness as T2 MRI contrast agents at high MR fields was confirmed from strong negative contrast enhancements in in vivo T2 MR images at a 9.4 T MR field after intravenous administration into mice tails.

Original language	English
Article number	1355
Journal	Nanomaterials
Volume	11
Issue number	5
DOIs	https://doi.org/10.3390/nano11051355
State	Published - May 2021

Keywords

High MR field
Ho2O3
MRI
Nanoparticles
Polyacrylic acid‐coating
Tb2O3

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Marasini, S., Yue, H., Ho, S. L., Park, J. A., Kim, S., Jung, K. H., Cha, H., Liu, S., Tegafaw, T., Ahmad, M. Y., Ghazanfari, A., Chae, K. S., Chang, Y., & Lee, G. H. (2021). Synthesis, characterizations, and 9.4 tesla t2 mr images of polyacrylic acid‐coated terbium(iii) and holmium(iii) oxide nanoparticles. Nanomaterials, 11(5), Article 1355. https://doi.org/10.3390/nano11051355

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title = "Synthesis, characterizations, and 9.4 tesla t2 mr images of polyacrylic acid‐coated terbium(iii) and holmium(iii) oxide nanoparticles",

abstract = "Polyacrylic acid (PAA)‐coated lanthanide oxide (Ln2O3) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T2) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r2 values were appreciable at a 3.0 T MR field and higher at a 9.4 T MR field, whereas their r1 values were negligible at all MR fields, indicating their exclusive induction of T2 relaxations with negligible induction of T1 relaxations. Their effectiveness as T2 MRI contrast agents at high MR fields was confirmed from strong negative contrast enhancements in in vivo T2 MR images at a 9.4 T MR field after intravenous administration into mice tails.",

keywords = "High MR field, Ho2O3, MRI, Nanoparticles, Polyacrylic acid‐coating, Tb2O3",

author = "Shanti Marasini and Huan Yue and Ho, {Son Long} and Park, {Ji Ae} and Soyeon Kim and Jung, {Ki Hye} and Hyunsil Cha and Shuwen Liu and Tirusew Tegafaw and Ahmad, {Mohammad Yaseen} and Adibehalsadat Ghazanfari and Chae, {Kwon Seok} and Yongmin Chang and Lee, {Gang Ho}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",

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month = may,

doi = "10.3390/nano11051355",

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AU - Marasini, Shanti

AU - Yue, Huan

AU - Ho, Son Long

AU - Park, Ji Ae

AU - Kim, Soyeon

AU - Jung, Ki Hye

AU - Cha, Hyunsil

AU - Liu, Shuwen

AU - Tegafaw, Tirusew

AU - Ahmad, Mohammad Yaseen

AU - Ghazanfari, Adibehalsadat

AU - Chae, Kwon Seok

AU - Chang, Yongmin

AU - Lee, Gang Ho

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PY - 2021/5

Y1 - 2021/5

N2 - Polyacrylic acid (PAA)‐coated lanthanide oxide (Ln2O3) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T2) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r2 values were appreciable at a 3.0 T MR field and higher at a 9.4 T MR field, whereas their r1 values were negligible at all MR fields, indicating their exclusive induction of T2 relaxations with negligible induction of T1 relaxations. Their effectiveness as T2 MRI contrast agents at high MR fields was confirmed from strong negative contrast enhancements in in vivo T2 MR images at a 9.4 T MR field after intravenous administration into mice tails.

AB - Polyacrylic acid (PAA)‐coated lanthanide oxide (Ln2O3) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T2) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r2 values were appreciable at a 3.0 T MR field and higher at a 9.4 T MR field, whereas their r1 values were negligible at all MR fields, indicating their exclusive induction of T2 relaxations with negligible induction of T1 relaxations. Their effectiveness as T2 MRI contrast agents at high MR fields was confirmed from strong negative contrast enhancements in in vivo T2 MR images at a 9.4 T MR field after intravenous administration into mice tails.

KW - High MR field

KW - Ho2O3

KW - MRI

KW - Nanoparticles

KW - Polyacrylic acid‐coating

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DO - 10.3390/nano11051355

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JO - Nanomaterials

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M1 - 1355

ER -

Synthesis, characterizations, and 9.4 tesla t2 mr images of polyacrylic acid‐coated terbium(iii) and holmium(iii) oxide nanoparticles

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