TY - GEN
T1 - Synthesis of gadolinium oxide nanocomposite particles for MRI and NCT applications
AU - Cheong, Inwoo
AU - Cho, Heuikyoung
PY - 2011
Y1 - 2011
N2 - MRI-active Gd 2O 3 core/SiO 2 shell/poly(2-methacryloyloxyethyl phosphorylcholine) corona composite nanoparticles (Gd 2O 3@SiO 2@PMPC NPs) have a number of attractive features in cancer diagnosis and neutron capture therapy (NCT).1 Monodisperse and highly crystalline Gd 2O 3 NPs were prepared using a polyol protocol to control the average particle size and surface properties. The Gd 2O 3 NPs were then functionalized with SiO 2 and a biomimetic layer of PMPC, to achieve reduced toxicity and enhanced nucleus affinity, for use as an MRI-active Gd-NCT agent.
AB - MRI-active Gd 2O 3 core/SiO 2 shell/poly(2-methacryloyloxyethyl phosphorylcholine) corona composite nanoparticles (Gd 2O 3@SiO 2@PMPC NPs) have a number of attractive features in cancer diagnosis and neutron capture therapy (NCT).1 Monodisperse and highly crystalline Gd 2O 3 NPs were prepared using a polyol protocol to control the average particle size and surface properties. The Gd 2O 3 NPs were then functionalized with SiO 2 and a biomimetic layer of PMPC, to achieve reduced toxicity and enhanced nucleus affinity, for use as an MRI-active Gd-NCT agent.
UR - http://www.scopus.com/inward/record.url?scp=84856707800&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84856707800
SN - 9780816910700
T3 - AIChE Annual Meeting, Conference Proceedings
BT - 11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings
T2 - 2011 AIChE Annual Meeting, 11AIChE
Y2 - 16 October 2011 through 21 October 2011
ER -
