Synthesis of gadolinium oxide nanocomposite particles for MRI and NCT applications

Inwoo Cheong; Heuikyoung Cho

Synthesis of gadolinium oxide nanocomposite particles for MRI and NCT applications

Inwoo Cheong
, Heuikyoung Cho

Kyungpook National University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

MRI-active Gd ₂O ₃ core/SiO ₂ shell/poly(2-methacryloyloxyethyl phosphorylcholine) corona composite nanoparticles (Gd ₂O ₃@SiO ₂@PMPC NPs) have a number of attractive features in cancer diagnosis and neutron capture therapy (NCT).1 Monodisperse and highly crystalline Gd ₂O ₃ NPs were prepared using a polyol protocol to control the average particle size and surface properties. The Gd ₂O ₃ NPs were then functionalized with SiO ₂ and a biomimetic layer of PMPC, to achieve reduced toxicity and enhanced nucleus affinity, for use as an MRI-active Gd-NCT agent.

Original language	English
Title of host publication	11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings
State	Published - 2011
Event	2011 AIChE Annual Meeting, 11AIChE - Minneapolis, MN, United States Duration: 16 Oct 2011 → 21 Oct 2011

Publication series

Name	AIChE Annual Meeting, Conference Proceedings

Conference

Conference	2011 AIChE Annual Meeting, 11AIChE
Country/Territory	United States
City	Minneapolis, MN
Period	16/10/11 → 21/10/11

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

@inproceedings{0b1e0ddec13c45b8b3918c1f7490bb92,

title = "Synthesis of gadolinium oxide nanocomposite particles for MRI and NCT applications",

abstract = "MRI-active Gd 2O 3 core/SiO 2 shell/poly(2-methacryloyloxyethyl phosphorylcholine) corona composite nanoparticles (Gd 2O 3@SiO 2@PMPC NPs) have a number of attractive features in cancer diagnosis and neutron capture therapy (NCT).1 Monodisperse and highly crystalline Gd 2O 3 NPs were prepared using a polyol protocol to control the average particle size and surface properties. The Gd 2O 3 NPs were then functionalized with SiO 2 and a biomimetic layer of PMPC, to achieve reduced toxicity and enhanced nucleus affinity, for use as an MRI-active Gd-NCT agent.",

author = "Inwoo Cheong and Heuikyoung Cho",

year = "2011",

language = "English",

isbn = "9780816910700",

series = "AIChE Annual Meeting, Conference Proceedings",

booktitle = "11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings",

note = "2011 AIChE Annual Meeting, 11AIChE ; Conference date: 16-10-2011 Through 21-10-2011",

}

TY - GEN

T1 - Synthesis of gadolinium oxide nanocomposite particles for MRI and NCT applications

AU - Cheong, Inwoo

AU - Cho, Heuikyoung

PY - 2011

Y1 - 2011

N2 - MRI-active Gd 2O 3 core/SiO 2 shell/poly(2-methacryloyloxyethyl phosphorylcholine) corona composite nanoparticles (Gd 2O 3@SiO 2@PMPC NPs) have a number of attractive features in cancer diagnosis and neutron capture therapy (NCT).1 Monodisperse and highly crystalline Gd 2O 3 NPs were prepared using a polyol protocol to control the average particle size and surface properties. The Gd 2O 3 NPs were then functionalized with SiO 2 and a biomimetic layer of PMPC, to achieve reduced toxicity and enhanced nucleus affinity, for use as an MRI-active Gd-NCT agent.

AB - MRI-active Gd 2O 3 core/SiO 2 shell/poly(2-methacryloyloxyethyl phosphorylcholine) corona composite nanoparticles (Gd 2O 3@SiO 2@PMPC NPs) have a number of attractive features in cancer diagnosis and neutron capture therapy (NCT).1 Monodisperse and highly crystalline Gd 2O 3 NPs were prepared using a polyol protocol to control the average particle size and surface properties. The Gd 2O 3 NPs were then functionalized with SiO 2 and a biomimetic layer of PMPC, to achieve reduced toxicity and enhanced nucleus affinity, for use as an MRI-active Gd-NCT agent.

UR - https://www.scopus.com/pages/publications/84856707800

M3 - Conference contribution

AN - SCOPUS:84856707800

SN - 9780816910700

T3 - AIChE Annual Meeting, Conference Proceedings

BT - 11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings

T2 - 2011 AIChE Annual Meeting, 11AIChE

Y2 - 16 October 2011 through 21 October 2011

ER -

Synthesis of gadolinium oxide nanocomposite particles for MRI and NCT applications

Abstract

Publication series

Conference

UN SDGs

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