Synthesis of Indolo[2,1- a ]isoquinolines via Copper-Catalyzed C-C Coupling and Cyclization of 2-(2-Bromoaryl)-1 H -indoles with 1,3-Diketones

Ha Kyeong Lee; Pham Duy Quang Dao; Young Su Kim; Chan Sik Cho

doi:10.1055/s-0036-1591589

Synthesis of Indolo[2,1- a ]isoquinolines via Copper-Catalyzed C-C Coupling and Cyclization of 2-(2-Bromoaryl)-1 H -indoles with 1,3-Diketones

Ha Kyeong Lee, Pham Duy Quang Dao, Young Su Kim, Chan Sik Cho

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

2-(2-Bromoaryl)-1 H -indoles are coupled and cyclized with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of copper(I) iodide along with a base to afford the corresponding indolo[2,1- a ]isoquinolines in moderate to good yields.

Original language	English
Pages (from-to)	3243-3249
Number of pages	7
Journal	Synthesis
Volume	50
Issue number	16
DOIs	https://doi.org/10.1055/s-0036-1591589
State	Published - 2018

Keywords

copper
coupling
cyclization
fused-ring systems
heterocycles

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10.1055/s-0036-1591589

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title = "Synthesis of Indolo[2,1- a ]isoquinolines via Copper-Catalyzed C-C Coupling and Cyclization of 2-(2-Bromoaryl)-1 H -indoles with 1,3-Diketones",

abstract = "2-(2-Bromoaryl)-1 H -indoles are coupled and cyclized with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of copper(I) iodide along with a base to afford the corresponding indolo[2,1- a ]isoquinolines in moderate to good yields.",

keywords = "copper, coupling, cyclization, fused-ring systems, heterocycles",

author = "Lee, \{Ha Kyeong\} and Dao, \{Pham Duy Quang\} and Kim, \{Young Su\} and Cho, \{Chan Sik\}",

note = "Publisher Copyright: {\textcopyright} Georg Thieme Verlag Stuttgart. New York.",

year = "2018",

doi = "10.1055/s-0036-1591589",

language = "English",

volume = "50",

pages = "3243--3249",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

number = "16",

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TY - JOUR

T1 - Synthesis of Indolo[2,1- a ]isoquinolines via Copper-Catalyzed C-C Coupling and Cyclization of 2-(2-Bromoaryl)-1 H -indoles with 1,3-Diketones

AU - Lee, Ha Kyeong

AU - Dao, Pham Duy Quang

AU - Kim, Young Su

AU - Cho, Chan Sik

N1 - Publisher Copyright: © Georg Thieme Verlag Stuttgart. New York.

PY - 2018

Y1 - 2018

N2 - 2-(2-Bromoaryl)-1 H -indoles are coupled and cyclized with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of copper(I) iodide along with a base to afford the corresponding indolo[2,1- a ]isoquinolines in moderate to good yields.

AB - 2-(2-Bromoaryl)-1 H -indoles are coupled and cyclized with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of copper(I) iodide along with a base to afford the corresponding indolo[2,1- a ]isoquinolines in moderate to good yields.

KW - copper

KW - coupling

KW - cyclization

KW - fused-ring systems

KW - heterocycles

UR - https://www.scopus.com/pages/publications/85051063547

U2 - 10.1055/s-0036-1591589

DO - 10.1055/s-0036-1591589

M3 - Article

AN - SCOPUS:85051063547

SN - 0039-7881

VL - 50

SP - 3243

EP - 3249

JO - Synthesis

JF - Synthesis

IS - 16

ER -

Synthesis of Indolo[2,1- a ]isoquinolines via Copper-Catalyzed C-C Coupling and Cyclization of 2-(2-Bromoaryl)-1 H -indoles with 1,3-Diketones

Abstract

Keywords

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