Synthesis of nanoparticle CT contrast agents: In vitro and in vivo studies

Sung June Kim; Wenlong Xu; Md Wasi Ahmad; Jong Su Baeck; Yongmin Chang; Ji Eun Bae; Kwon Seok Chae; Tae Jeong Kim; Ji Ae Park; Gang Ho Lee

doi:10.1088/1468-6996/16/5/055003

Synthesis of nanoparticle CT contrast agents: In vitro and in vivo studies

Sung June Kim, Wenlong Xu, Md Wasi Ahmad, Jong Su Baeck, Yongmin Chang, Ji Eun Bae, Kwon Seok Chae, Tae Jeong Kim, Ji Ae Park, Gang Ho Lee

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Water-soluble and biocompatible D-glucuronic acid coated Na₂WO₄ and BaCO₃ nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ±0.1 and 2.8 ±0.1 nm for D-glucuronic acid coated Na₂WO₄ and BaCO₃ nanoparticles, respectively. All the nanoparticles exhibited a strong x-ray attenuation. In vivo CT images were obtained after intravenous injection of an aqueous sample suspension of D-glucuronic acid coated Na₂WO₄ nanoparticles, and positive contrast enhancements in the kidney were clearly shown. These findings indicate that the nanoparticles reported in this study may be promising CT contrast agents.

Original language	English
Article number	055003
Journal	Science and Technology of Advanced Materials
Volume	16
Issue number	5
DOIs	https://doi.org/10.1088/1468-6996/16/5/055003
State	Published - 9 Oct 2015

Keywords

CT contrast agent
NaWO, BaCO
nanoparticle

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10.1088/1468-6996/16/5/055003

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title = "Synthesis of nanoparticle CT contrast agents: In vitro and in vivo studies",

abstract = "Water-soluble and biocompatible D-glucuronic acid coated Na2WO4 and BaCO3 nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ±0.1 and 2.8 ±0.1 nm for D-glucuronic acid coated Na2WO4 and BaCO3 nanoparticles, respectively. All the nanoparticles exhibited a strong x-ray attenuation. In vivo CT images were obtained after intravenous injection of an aqueous sample suspension of D-glucuronic acid coated Na2WO4 nanoparticles, and positive contrast enhancements in the kidney were clearly shown. These findings indicate that the nanoparticles reported in this study may be promising CT contrast agents.",

keywords = "CT contrast agent, NaWO, BaCO, nanoparticle",

author = "Kim, {Sung June} and Wenlong Xu and Ahmad, {Md Wasi} and Baeck, {Jong Su} and Yongmin Chang and Bae, {Ji Eun} and Chae, {Kwon Seok} and Kim, {Tae Jeong} and Park, {Ji Ae} and Lee, {Gang Ho}",

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doi = "10.1088/1468-6996/16/5/055003",

language = "English",

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T1 - Synthesis of nanoparticle CT contrast agents

T2 - In vitro and in vivo studies

AU - Kim, Sung June

AU - Xu, Wenlong

AU - Ahmad, Md Wasi

AU - Baeck, Jong Su

AU - Chang, Yongmin

AU - Bae, Ji Eun

AU - Chae, Kwon Seok

AU - Kim, Tae Jeong

AU - Park, Ji Ae

AU - Lee, Gang Ho

PY - 2015/10/9

Y1 - 2015/10/9

N2 - Water-soluble and biocompatible D-glucuronic acid coated Na2WO4 and BaCO3 nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ±0.1 and 2.8 ±0.1 nm for D-glucuronic acid coated Na2WO4 and BaCO3 nanoparticles, respectively. All the nanoparticles exhibited a strong x-ray attenuation. In vivo CT images were obtained after intravenous injection of an aqueous sample suspension of D-glucuronic acid coated Na2WO4 nanoparticles, and positive contrast enhancements in the kidney were clearly shown. These findings indicate that the nanoparticles reported in this study may be promising CT contrast agents.

AB - Water-soluble and biocompatible D-glucuronic acid coated Na2WO4 and BaCO3 nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ±0.1 and 2.8 ±0.1 nm for D-glucuronic acid coated Na2WO4 and BaCO3 nanoparticles, respectively. All the nanoparticles exhibited a strong x-ray attenuation. In vivo CT images were obtained after intravenous injection of an aqueous sample suspension of D-glucuronic acid coated Na2WO4 nanoparticles, and positive contrast enhancements in the kidney were clearly shown. These findings indicate that the nanoparticles reported in this study may be promising CT contrast agents.

KW - CT contrast agent

KW - NaWO, BaCO

KW - nanoparticle

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DO - 10.1088/1468-6996/16/5/055003

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JO - Science and Technology of Advanced Materials

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Synthesis of nanoparticle CT contrast agents: In vitro and in vivo studies

Abstract

Keywords

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