Synthesis of novel cholesterol-based cationic lipids for gene delivery

Bieong Kil Kim; Kyung Oh Doh; Joo Hyeung Nam; Hyungu Kang; Jong Gu Park; Ik Jae Moon; Young Bae Seu

doi:10.1016/j.bmcl.2009.04.036

Synthesis of novel cholesterol-based cationic lipids for gene delivery

Bieong Kil Kim, Kyung Oh Doh, Joo Hyeung Nam, Hyungu Kang, Jong Gu Park, Ik Jae Moon, Young Bae Seu

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively.

Original language	English
Pages (from-to)	2986-2989
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2009.04.036
State	Published - 1 Jun 2009

Keywords

Cationic lipids
Cholesterol derivatives
Cyanoethylation
Gene delivery

Access to Document

10.1016/j.bmcl.2009.04.036

Cite this

@article{8beb8e54cdfa48c79fd7b1debcdb10a7,

title = "Synthesis of novel cholesterol-based cationic lipids for gene delivery",

abstract = "The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively.",

keywords = "Cationic lipids, Cholesterol derivatives, Cyanoethylation, Gene delivery",

author = "Kim, {Bieong Kil} and Doh, {Kyung Oh} and Nam, {Joo Hyeung} and Hyungu Kang and Park, {Jong Gu} and Moon, {Ik Jae} and Seu, {Young Bae}",

year = "2009",

month = jun,

day = "1",

doi = "10.1016/j.bmcl.2009.04.036",

language = "English",

volume = "19",

pages = "2986--2989",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "11",

}

TY - JOUR

T1 - Synthesis of novel cholesterol-based cationic lipids for gene delivery

AU - Kim, Bieong Kil

AU - Doh, Kyung Oh

AU - Nam, Joo Hyeung

AU - Kang, Hyungu

AU - Park, Jong Gu

AU - Moon, Ik Jae

AU - Seu, Young Bae

PY - 2009/6/1

Y1 - 2009/6/1

N2 - The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively.

AB - The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively.

KW - Cationic lipids

KW - Cholesterol derivatives

KW - Cyanoethylation

KW - Gene delivery

UR - http://www.scopus.com/inward/record.url?scp=65549085324&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.04.036

DO - 10.1016/j.bmcl.2009.04.036

M3 - Article

C2 - 19409781

AN - SCOPUS:65549085324

SN - 0960-894X

VL - 19

SP - 2986

EP - 2989

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

Synthesis of novel cholesterol-based cationic lipids for gene delivery

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this