Synthesis of PET and SPECT radiotracers using inverse electron-demand Diels-Alder reaction

Sajid Mushtaq; Jongho Jeon

doi:10.14478/ace.2017.1021

Synthesis of PET and SPECT radiotracers using inverse electron-demand Diels-Alder reaction

Sajid Mushtaq, Jongho Jeon

Department of Applied Chemistry

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Inverse electron-demand Diels-Alder reactions (IEDDA) between tetrazine derivatives and strained dienophiles have attracted a lot of attention for the efficient conjugation of biomolecules, polymers, and nanomaterials. Excellent specificity, exceptionally fast reaction rate, and biocompatibility are key features of IEDDA. Therefore, it has also been applied to the development of new labeling methods using several radioisotopes and development of radiotracers to carry out various nuclear imaging as well as therapeutic studies. The purpose of this review is to introduce the reader to the recent advances and applications of IEDDA in the fields of radiochemistry and nuclear medicine.

Original language	English
Pages (from-to)	141-152
Number of pages	12
Journal	Applied Chemistry for Engineering
Volume	28
Issue number	2
DOIs	https://doi.org/10.14478/ace.2017.1021
State	Published - Apr 2017

Keywords

Diagnosis
Inverse electron-demand Diels-Alder reaction
Nuclear imaging
Radiolabeling
Therapy

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10.14478/ace.2017.1021

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title = "Synthesis of PET and SPECT radiotracers using inverse electron-demand Diels-Alder reaction",

abstract = "Inverse electron-demand Diels-Alder reactions (IEDDA) between tetrazine derivatives and strained dienophiles have attracted a lot of attention for the efficient conjugation of biomolecules, polymers, and nanomaterials. Excellent specificity, exceptionally fast reaction rate, and biocompatibility are key features of IEDDA. Therefore, it has also been applied to the development of new labeling methods using several radioisotopes and development of radiotracers to carry out various nuclear imaging as well as therapeutic studies. The purpose of this review is to introduce the reader to the recent advances and applications of IEDDA in the fields of radiochemistry and nuclear medicine.",

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Synthesis of PET and SPECT radiotracers using inverse electron-demand Diels-Alder reaction

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Keywords

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