Synthesis of silver nanoparticles using Leucas biflora (Vahl) Sm. Leaf extracts and their activity on breast cancer (MDA-MB-231) cells

K. Chitra; M. Sureshkumar; N. Vijayakumar; Jamaan S. Ajarem; Ahmed A. Allam; Woong Kim; P. Kumar

doi:10.1016/j.matlet.2022.131706

Synthesis of silver nanoparticles using Leucas biflora (Vahl) Sm. Leaf extracts and their activity on breast cancer (MDA-MB-231) cells

K. Chitra, M. Sureshkumar, N. Vijayakumar, Jamaan S. Ajarem, Ahmed A. Allam, Woong Kim, P. Kumar

Department of Environmental Engineering

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The goal of this study is to develop the Leucas biflora (Vahl)Sm. leaf extract fabricated silver nanoparticles (LbLE-Ag-NPs) as a potential anticancer agent using a simple green chemistry approach. Synthesized LbLE-AgNPs were found to be hexagonal shape, crystalline nature with a size range of 40–98 nm, and have zeta potential at −0.138 mV, according to the analytical data. The functional groups bonded with LbLE-Ag-NPs were screened as C-Br, C-Cl, OH, C-O-C, and C = C, etc. LbLE-AgNPs exhibited an effective dose-dependent anti-cancerous activity on MDA-MB-231 (breast cancer cell line) and the minimum inhibitory concentration (IC₅₀) value is measured as 95 ± 0.21 µg/ml. The induction of apoptosis was also confirmed by fluorescence-based staining upon treatment. The resultant LbLE-Ag-NPs could be used in the anticancer progress as an alternate agent after the detailed scrutinize.

Original language	English
Article number	131706
Journal	Materials Letters
Volume	312
DOIs	https://doi.org/10.1016/j.matlet.2022.131706
State	Published - 1 Apr 2022

Keywords

Anticancer
Leucas biflora
Phyto-fabrication
Silver Nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.matlet.2022.131706

Cite this

@article{b57564d54f7c41af858de6ccb1717642,

title = "Synthesis of silver nanoparticles using Leucas biflora (Vahl) Sm. Leaf extracts and their activity on breast cancer (MDA-MB-231) cells",

abstract = "The goal of this study is to develop the Leucas biflora (Vahl)Sm. leaf extract fabricated silver nanoparticles (LbLE-Ag-NPs) as a potential anticancer agent using a simple green chemistry approach. Synthesized LbLE-AgNPs were found to be hexagonal shape, crystalline nature with a size range of 40–98 nm, and have zeta potential at −0.138 mV, according to the analytical data. The functional groups bonded with LbLE-Ag-NPs were screened as C-Br, C-Cl, OH, C-O-C, and C = C, etc. LbLE-AgNPs exhibited an effective dose-dependent anti-cancerous activity on MDA-MB-231 (breast cancer cell line) and the minimum inhibitory concentration (IC50) value is measured as 95 ± 0.21 µg/ml. The induction of apoptosis was also confirmed by fluorescence-based staining upon treatment. The resultant LbLE-Ag-NPs could be used in the anticancer progress as an alternate agent after the detailed scrutinize.",

keywords = "Anticancer, Leucas biflora, Phyto-fabrication, Silver Nanoparticles",

author = "K. Chitra and M. Sureshkumar and N. Vijayakumar and Ajarem, {Jamaan S.} and Allam, {Ahmed A.} and Woong Kim and P. Kumar",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = apr,

day = "1",

doi = "10.1016/j.matlet.2022.131706",

language = "English",

volume = "312",

journal = "Materials Letters",

issn = "0167-577X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Synthesis of silver nanoparticles using Leucas biflora (Vahl) Sm. Leaf extracts and their activity on breast cancer (MDA-MB-231) cells

AU - Chitra, K.

AU - Sureshkumar, M.

AU - Vijayakumar, N.

AU - Ajarem, Jamaan S.

AU - Allam, Ahmed A.

AU - Kim, Woong

AU - Kumar, P.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - The goal of this study is to develop the Leucas biflora (Vahl)Sm. leaf extract fabricated silver nanoparticles (LbLE-Ag-NPs) as a potential anticancer agent using a simple green chemistry approach. Synthesized LbLE-AgNPs were found to be hexagonal shape, crystalline nature with a size range of 40–98 nm, and have zeta potential at −0.138 mV, according to the analytical data. The functional groups bonded with LbLE-Ag-NPs were screened as C-Br, C-Cl, OH, C-O-C, and C = C, etc. LbLE-AgNPs exhibited an effective dose-dependent anti-cancerous activity on MDA-MB-231 (breast cancer cell line) and the minimum inhibitory concentration (IC50) value is measured as 95 ± 0.21 µg/ml. The induction of apoptosis was also confirmed by fluorescence-based staining upon treatment. The resultant LbLE-Ag-NPs could be used in the anticancer progress as an alternate agent after the detailed scrutinize.

AB - The goal of this study is to develop the Leucas biflora (Vahl)Sm. leaf extract fabricated silver nanoparticles (LbLE-Ag-NPs) as a potential anticancer agent using a simple green chemistry approach. Synthesized LbLE-AgNPs were found to be hexagonal shape, crystalline nature with a size range of 40–98 nm, and have zeta potential at −0.138 mV, according to the analytical data. The functional groups bonded with LbLE-Ag-NPs were screened as C-Br, C-Cl, OH, C-O-C, and C = C, etc. LbLE-AgNPs exhibited an effective dose-dependent anti-cancerous activity on MDA-MB-231 (breast cancer cell line) and the minimum inhibitory concentration (IC50) value is measured as 95 ± 0.21 µg/ml. The induction of apoptosis was also confirmed by fluorescence-based staining upon treatment. The resultant LbLE-Ag-NPs could be used in the anticancer progress as an alternate agent after the detailed scrutinize.

KW - Anticancer

KW - Leucas biflora

KW - Phyto-fabrication

KW - Silver Nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=85122704695&partnerID=8YFLogxK

U2 - 10.1016/j.matlet.2022.131706

DO - 10.1016/j.matlet.2022.131706

M3 - Article

AN - SCOPUS:85122704695

SN - 0167-577X

VL - 312

JO - Materials Letters

JF - Materials Letters

M1 - 131706

ER -

Synthesis of silver nanoparticles using Leucas biflora (Vahl) Sm. Leaf extracts and their activity on breast cancer (MDA-MB-231) cells

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this