Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities

Nam Tae Woo; Sun Yong Jin; Dae Jin Cho; Nam Sun Kim; Eun Hyung Bae; Ducky Han; Byung Hoon Han; Young Hwa Kang

doi:10.1007/BF02974047

Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities

Nam Tae Woo, Sun Yong Jin, Dae Jin Cho, Nam Sun Kim, Eun Hyung Bae, Ducky Han, Byung Hoon Han, Young Hwa Kang

Department of Horticultural Science

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.

Original language	English
Pages (from-to)	80-84
Number of pages	5
Journal	Archives of Pharmacal Research
Volume	20
Issue number	1
DOIs	https://doi.org/10.1007/BF02974047
State	Published - Feb 1997

Keywords

PAF-receptor binding antagonistic activity
Platelet anti-aggregatory activities
Substituted cinnamoyl tyramine amides

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10.1007/BF02974047

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title = "Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities",

abstract = "Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.",

keywords = "PAF-receptor binding antagonistic activity, Platelet anti-aggregatory activities, Substituted cinnamoyl tyramine amides",

author = "Woo, {Nam Tae} and Jin, {Sun Yong} and Cho, {Dae Jin} and Kim, {Nam Sun} and Bae, {Eun Hyung} and Ducky Han and Han, {Byung Hoon} and Kang, {Young Hwa}",

year = "1997",

month = feb,

doi = "10.1007/BF02974047",

language = "English",

volume = "20",

pages = "80--84",

journal = "Archives of Pharmacal Research",

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TY - JOUR

T1 - Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities

AU - Woo, Nam Tae

AU - Jin, Sun Yong

AU - Cho, Dae Jin

AU - Kim, Nam Sun

AU - Bae, Eun Hyung

AU - Han, Ducky

AU - Han, Byung Hoon

AU - Kang, Young Hwa

PY - 1997/2

Y1 - 1997/2

N2 - Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.

AB - Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.

KW - PAF-receptor binding antagonistic activity

KW - Platelet anti-aggregatory activities

KW - Substituted cinnamoyl tyramine amides

UR - http://www.scopus.com/inward/record.url?scp=20544466143&partnerID=8YFLogxK

U2 - 10.1007/BF02974047

DO - 10.1007/BF02974047

M3 - Article

AN - SCOPUS:20544466143

SN - 0253-6269

VL - 20

SP - 80

EP - 84

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 1

ER -

Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities

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Keywords

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