Systematic Approach to Mimic Phenolic Natural Polymers for Biofabrication

Hyeju Han, Kyueui Lee

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

In nature, phenolic biopolymers are utilized as functional tools and molecular crosslinkers to control the mechanical properties of biomaterials. Of particular interest are phenolic proteins/polysaccharides from living organisms, which are rich in catechol and/or gallol groups. Their strong underwater adhesion is attributed to the representative phenolic molecule, catechol, which stimulates intermolecular and intramolecular crosslinking induced by oxidative polymerization. Significant efforts have been made to understand the underlying chemistries, and researchers have developed functional biomaterials by mimicking the systems. Owing to their unique biocompatibility and ability to transform their mechanical properties, phenolic polymers have revolutionized biotechnologies. In this review, we highlight the bottom-up approaches for mimicking polyphenolic materials in nature and recent advances in related biomedical applications. We expect that this review will contribute to the rational design and synthesis of polyphenolic functional biomaterials and facilitate the production of related applications.

Original languageEnglish
Article number1282
JournalPolymers
Volume14
Issue number7
DOIs
StatePublished - 1 Apr 2022

Keywords

  • biofabrication
  • biomaterials
  • biomimetics
  • biopolymers
  • polyphenols

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