Targeted images of KB cells using folate-conjugated gold nanoparticles

Pierson Rathinaraj; Kyubae Lee; Soo Young Park; Inn Kyu Kang

doi:10.1186/s11671-014-0725-y

Targeted images of KB cells using folate-conjugated gold nanoparticles

Pierson Rathinaraj, Kyubae Lee, Soo Young Park, Inn Kyu Kang

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membranes and facilitate the transit of the nanoparticles across the cell membrane. Finally, a fluorescence dye (Atto) was conjugated to the nanoparticles to visualize their internalization into KB cells. After culture of the cells in a medium containing GM and folate-conjugated GM (GF), the interaction of surface-modified gold nanoparticles with KB cells was studied.

Original language	English
Article number	5
Journal	Nanoscale Research Letters
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s11671-014-0725-y
State	Published - 2015

Keywords

Folic acid
Gold nanoparticles
Intracellular uptake
KB cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s11671-014-0725-y

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title = "Targeted images of KB cells using folate-conjugated gold nanoparticles",

abstract = "Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membranes and facilitate the transit of the nanoparticles across the cell membrane. Finally, a fluorescence dye (Atto) was conjugated to the nanoparticles to visualize their internalization into KB cells. After culture of the cells in a medium containing GM and folate-conjugated GM (GF), the interaction of surface-modified gold nanoparticles with KB cells was studied.",

keywords = "Folic acid, Gold nanoparticles, Intracellular uptake, KB cells",

author = "Pierson Rathinaraj and Kyubae Lee and Park, {Soo Young} and Kang, {Inn Kyu}",

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AU - Rathinaraj, Pierson

AU - Lee, Kyubae

AU - Park, Soo Young

AU - Kang, Inn Kyu

PY - 2015

Y1 - 2015

N2 - Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membranes and facilitate the transit of the nanoparticles across the cell membrane. Finally, a fluorescence dye (Atto) was conjugated to the nanoparticles to visualize their internalization into KB cells. After culture of the cells in a medium containing GM and folate-conjugated GM (GF), the interaction of surface-modified gold nanoparticles with KB cells was studied.

AB - Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membranes and facilitate the transit of the nanoparticles across the cell membrane. Finally, a fluorescence dye (Atto) was conjugated to the nanoparticles to visualize their internalization into KB cells. After culture of the cells in a medium containing GM and folate-conjugated GM (GF), the interaction of surface-modified gold nanoparticles with KB cells was studied.

KW - Folic acid

KW - Gold nanoparticles

KW - Intracellular uptake

KW - KB cells

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JO - Nanoscale Research Letters

JF - Nanoscale Research Letters

IS - 1

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ER -

Targeted images of KB cells using folate-conjugated gold nanoparticles

Abstract

Keywords

UN SDGs

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