Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model

Hye Lim Lee; Kyung Min Lee; Sun Joo Son; Sung Hun Hwang; Hee Jung Cho

Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model

Hye Lim Lee, Kyung Min Lee, Sun Joo Son, Sung Hun Hwang, Hee Jung Cho

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

153 Scopus citations

Abstract

Proinflammatory mediators, such as tumor necrosis factor (TNF) α, interleukin (IL)-1βand IL-6 have been found to play a key role in the propagation of persistent pain states. We investigated the temporal expressions of the mRNAs and the receptor mRNAs of TNFα, IL-1β and IL-6 in rat dorsal root ganglia and spinal cord in a chronic constriction injury model of neuropathic pain. Our results show that the maximal induction of IL-6 mRNA occurred later and was more sustained than those of TNFα and IL-1β mRNAs in the dorsal root ganglia and spinal cord following chronic injury. Receptors mRNAs, except TNF receptor 2 and gp130 m RNAs, showed temporal profiles that were similar to those of their cytokine mRNAs. Additionally, the induction of the mRNAs of cytokines and of their receptors in the dorsal root ganglia was more rapid than in the spinal cord.

Original language	English
Pages (from-to)	2807-2811
Number of pages	5
Journal	NeuroReport
Volume	15
Issue number	18
State	Published - 22 Dec 2004

Keywords

Dorsal root ganglion
Interleukin-1β
Interleukin-6
Neuropathic pain
Reverse transcription-polymerase chain reaction
Spinal cord
Tumor necrosis factor α

Cite this

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title = "Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model",

abstract = "Proinflammatory mediators, such as tumor necrosis factor (TNF) α, interleukin (IL)-1βand IL-6 have been found to play a key role in the propagation of persistent pain states. We investigated the temporal expressions of the mRNAs and the receptor mRNAs of TNFα, IL-1β and IL-6 in rat dorsal root ganglia and spinal cord in a chronic constriction injury model of neuropathic pain. Our results show that the maximal induction of IL-6 mRNA occurred later and was more sustained than those of TNFα and IL-1β mRNAs in the dorsal root ganglia and spinal cord following chronic injury. Receptors mRNAs, except TNF receptor 2 and gp130 m RNAs, showed temporal profiles that were similar to those of their cytokine mRNAs. Additionally, the induction of the mRNAs of cytokines and of their receptors in the dorsal root ganglia was more rapid than in the spinal cord.",

keywords = "Dorsal root ganglion, Interleukin-1β, Interleukin-6, Neuropathic pain, Reverse transcription-polymerase chain reaction, Spinal cord, Tumor necrosis factor α",

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T1 - Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model

AU - Lee, Hye Lim

AU - Lee, Kyung Min

AU - Son, Sun Joo

AU - Hwang, Sung Hun

AU - Cho, Hee Jung

PY - 2004/12/22

Y1 - 2004/12/22

N2 - Proinflammatory mediators, such as tumor necrosis factor (TNF) α, interleukin (IL)-1βand IL-6 have been found to play a key role in the propagation of persistent pain states. We investigated the temporal expressions of the mRNAs and the receptor mRNAs of TNFα, IL-1β and IL-6 in rat dorsal root ganglia and spinal cord in a chronic constriction injury model of neuropathic pain. Our results show that the maximal induction of IL-6 mRNA occurred later and was more sustained than those of TNFα and IL-1β mRNAs in the dorsal root ganglia and spinal cord following chronic injury. Receptors mRNAs, except TNF receptor 2 and gp130 m RNAs, showed temporal profiles that were similar to those of their cytokine mRNAs. Additionally, the induction of the mRNAs of cytokines and of their receptors in the dorsal root ganglia was more rapid than in the spinal cord.

AB - Proinflammatory mediators, such as tumor necrosis factor (TNF) α, interleukin (IL)-1βand IL-6 have been found to play a key role in the propagation of persistent pain states. We investigated the temporal expressions of the mRNAs and the receptor mRNAs of TNFα, IL-1β and IL-6 in rat dorsal root ganglia and spinal cord in a chronic constriction injury model of neuropathic pain. Our results show that the maximal induction of IL-6 mRNA occurred later and was more sustained than those of TNFα and IL-1β mRNAs in the dorsal root ganglia and spinal cord following chronic injury. Receptors mRNAs, except TNF receptor 2 and gp130 m RNAs, showed temporal profiles that were similar to those of their cytokine mRNAs. Additionally, the induction of the mRNAs of cytokines and of their receptors in the dorsal root ganglia was more rapid than in the spinal cord.

KW - Dorsal root ganglion

KW - Interleukin-1β

KW - Interleukin-6

KW - Neuropathic pain

KW - Reverse transcription-polymerase chain reaction

KW - Spinal cord

KW - Tumor necrosis factor α

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M3 - Article

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JO - NeuroReport

JF - NeuroReport

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Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model

Abstract

Keywords

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