Terpenoids from citrus unshiu peels and their effects on no production

Thi Oanh Vu; Wonyoung Seo; Jeong Hyung Lee; Byung Sun Min; Jeong Ah Kim

doi:10.20307/nps.2020.26.2.176

Terpenoids from citrus unshiu peels and their effects on no production

Thi Oanh Vu, Wonyoung Seo, Jeong Hyung Lee, Byung Sun Min, Jeong Ah Kim

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Two new compounds, 3-methyl-but-2-en-1-yl-1-O-β-xylopyranosyl-(1ʺ→2ʹ)-O-β-glucopyranoside (1) and 1-O-β-glucopyranosyl-6-hydroxy-2-methyl-hep-2-enoic acid (2), along with sixteen known terpenoids were isolated from the peels of Citrus unshiu Markov. Their structures were elucidated based on extensive NMR analyses (¹H NMR,¹³C NMR, DEPT, COSY, HMQC, and HMBC) and high-resolution mass spectrometry. In addition, all isolates (1-18) were tested their effects on nitric oxide (NO) production in RAW264.7 cells. Limonin (15) showed to inhibit LPS-induced NO production in a concentration-dependent manner without cytotoxicity.

Original language	English
Pages (from-to)	176-181
Number of pages	6
Journal	Natural Product Sciences
Volume	26
Issue number	2
DOIs	https://doi.org/10.20307/nps.2020.26.2.176
State	Published - 2020

Keywords

Citrus unshiu Markov
NO production
Terpenoids

Access to Document

10.20307/nps.2020.26.2.176

Cite this

@article{aab736938ff844de9f927d525cd383eb,

title = "Terpenoids from citrus unshiu peels and their effects on no production",

abstract = "Two new compounds, 3-methyl-but-2-en-1-yl-1-O-β-xylopyranosyl-(1ʺ→2ʹ)-O-β-glucopyranoside (1) and 1-O-β-glucopyranosyl-6-hydroxy-2-methyl-hep-2-enoic acid (2), along with sixteen known terpenoids were isolated from the peels of Citrus unshiu Markov. Their structures were elucidated based on extensive NMR analyses (1H NMR,13C NMR, DEPT, COSY, HMQC, and HMBC) and high-resolution mass spectrometry. In addition, all isolates (1-18) were tested their effects on nitric oxide (NO) production in RAW264.7 cells. Limonin (15) showed to inhibit LPS-induced NO production in a concentration-dependent manner without cytotoxicity.",

keywords = "Citrus unshiu Markov, NO production, Terpenoids",

author = "Vu, {Thi Oanh} and Wonyoung Seo and Lee, {Jeong Hyung} and Min, {Byung Sun} and Kim, {Jeong Ah}",

year = "2020",

doi = "10.20307/nps.2020.26.2.176",

language = "English",

volume = "26",

pages = "176--181",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

number = "2",

}

TY - JOUR

T1 - Terpenoids from citrus unshiu peels and their effects on no production

AU - Vu, Thi Oanh

AU - Seo, Wonyoung

AU - Lee, Jeong Hyung

AU - Min, Byung Sun

AU - Kim, Jeong Ah

PY - 2020

Y1 - 2020

N2 - Two new compounds, 3-methyl-but-2-en-1-yl-1-O-β-xylopyranosyl-(1ʺ→2ʹ)-O-β-glucopyranoside (1) and 1-O-β-glucopyranosyl-6-hydroxy-2-methyl-hep-2-enoic acid (2), along with sixteen known terpenoids were isolated from the peels of Citrus unshiu Markov. Their structures were elucidated based on extensive NMR analyses (1H NMR,13C NMR, DEPT, COSY, HMQC, and HMBC) and high-resolution mass spectrometry. In addition, all isolates (1-18) were tested their effects on nitric oxide (NO) production in RAW264.7 cells. Limonin (15) showed to inhibit LPS-induced NO production in a concentration-dependent manner without cytotoxicity.

AB - Two new compounds, 3-methyl-but-2-en-1-yl-1-O-β-xylopyranosyl-(1ʺ→2ʹ)-O-β-glucopyranoside (1) and 1-O-β-glucopyranosyl-6-hydroxy-2-methyl-hep-2-enoic acid (2), along with sixteen known terpenoids were isolated from the peels of Citrus unshiu Markov. Their structures were elucidated based on extensive NMR analyses (1H NMR,13C NMR, DEPT, COSY, HMQC, and HMBC) and high-resolution mass spectrometry. In addition, all isolates (1-18) were tested their effects on nitric oxide (NO) production in RAW264.7 cells. Limonin (15) showed to inhibit LPS-induced NO production in a concentration-dependent manner without cytotoxicity.

KW - Citrus unshiu Markov

KW - NO production

KW - Terpenoids

UR - http://www.scopus.com/inward/record.url?scp=85096716977&partnerID=8YFLogxK

U2 - 10.20307/nps.2020.26.2.176

DO - 10.20307/nps.2020.26.2.176

M3 - Article

AN - SCOPUS:85096716977

SN - 1226-3907

VL - 26

SP - 176

EP - 181

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 2

ER -

Terpenoids from citrus unshiu peels and their effects on no production

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this