Abstract
Reports of testicular leiomyosarcoma are extremely rare in the veterinary literature. Here we report a case of testicular leiomyosarcoma occurring in a 32-weeks-old male senescence marker protein 30 (SMP30) knockout mouse. Grossly, a testicular mass completely replaced the right testis. The mass had a diameter of 1.6×0.9cm, and was well-encapsulated and firm. The cut surface showed heterogeneous white and yellow-brownish components with multifocal hemorrhages. Microscopically, the mass was composed of interlacing bundles of neoplastic cells characterized by a spindle-shaped appearance with elongated blunt-end nuclei and frequently observed mitotic figures. Immunohistochemically, the neoplastic cells showed strong positivity for vimentin and α-smooth muscle actin. Finally, present case was diagnosed as testicular leiomyosarcoma in an SMP30 knockout mouse.
| Original language | English |
|---|---|
| Pages (from-to) | 239-241 |
| Number of pages | 3 |
| Journal | Pakistan Veterinary Journal |
| Volume | 37 |
| Issue number | 2 |
| State | Published - 2017 |
Keywords
- Mouse
- SMP30
- Testicular leiomyosarcoma
- Vimentin
- α-SMA
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