TGF-β1 polymorphism determines the progression of joint damage in rheumatoid arthritis

S. Y. Kim; S. W. Han; G. W. Kim; J. M. Lee; Young Mo Kang

doi:10.1080/03009740410010344

TGF-β1 polymorphism determines the progression of joint damage in rheumatoid arthritis

S. Y. Kim, S. W. Han, G. W. Kim, J. M. Lee, Young Mo Kang

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Objective: To determine whether transforming growth factor-β1 (TGF-β1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) and to analyse whether they can affect the progression of radiographic severity. Methods: A total of 143 RA patients and 148 healthy unrelated controls were tested for the TGF-β1 polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The TGF-β1 polymorphisms were not associated with susceptibility to RA, although there was a trend that -509C/T and the 869T/C polymorphisms were associated with RA in the male population. The progression of radiographic severity, which was defined by a modified Sharp score plotted against disease duration, was significantly faster in the carrier of T allele at the -509 (p = 0.048). Conclusion: Our data support the hypothesis that TGF-β1 polymorphism may determine the progression of joint destruction in RA.

Original language	English
Pages (from-to)	389-394
Number of pages	6
Journal	Scandinavian Journal of Rheumatology
Volume	33
Issue number	6
DOIs	https://doi.org/10.1080/03009740410010344
State	Published - 2004

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title = "TGF-β1 polymorphism determines the progression of joint damage in rheumatoid arthritis",

abstract = "Objective: To determine whether transforming growth factor-β1 (TGF-β1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) and to analyse whether they can affect the progression of radiographic severity. Methods: A total of 143 RA patients and 148 healthy unrelated controls were tested for the TGF-β1 polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The TGF-β1 polymorphisms were not associated with susceptibility to RA, although there was a trend that -509C/T and the 869T/C polymorphisms were associated with RA in the male population. The progression of radiographic severity, which was defined by a modified Sharp score plotted against disease duration, was significantly faster in the carrier of T allele at the -509 (p = 0.048). Conclusion: Our data support the hypothesis that TGF-β1 polymorphism may determine the progression of joint destruction in RA.",

author = "Kim, {S. Y.} and Han, {S. W.} and Kim, {G. W.} and Lee, {J. M.} and Kang, {Young Mo}",

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T1 - TGF-β1 polymorphism determines the progression of joint damage in rheumatoid arthritis

AU - Kim, S. Y.

AU - Han, S. W.

AU - Kim, G. W.

AU - Lee, J. M.

AU - Kang, Young Mo

PY - 2004

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N2 - Objective: To determine whether transforming growth factor-β1 (TGF-β1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) and to analyse whether they can affect the progression of radiographic severity. Methods: A total of 143 RA patients and 148 healthy unrelated controls were tested for the TGF-β1 polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The TGF-β1 polymorphisms were not associated with susceptibility to RA, although there was a trend that -509C/T and the 869T/C polymorphisms were associated with RA in the male population. The progression of radiographic severity, which was defined by a modified Sharp score plotted against disease duration, was significantly faster in the carrier of T allele at the -509 (p = 0.048). Conclusion: Our data support the hypothesis that TGF-β1 polymorphism may determine the progression of joint destruction in RA.

AB - Objective: To determine whether transforming growth factor-β1 (TGF-β1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) and to analyse whether they can affect the progression of radiographic severity. Methods: A total of 143 RA patients and 148 healthy unrelated controls were tested for the TGF-β1 polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The TGF-β1 polymorphisms were not associated with susceptibility to RA, although there was a trend that -509C/T and the 869T/C polymorphisms were associated with RA in the male population. The progression of radiographic severity, which was defined by a modified Sharp score plotted against disease duration, was significantly faster in the carrier of T allele at the -509 (p = 0.048). Conclusion: Our data support the hypothesis that TGF-β1 polymorphism may determine the progression of joint destruction in RA.

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TGF-β1 polymorphism determines the progression of joint damage in rheumatoid arthritis

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