The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion

Sang Hyun Kim; Hyo Hyun Park; Soyoung Lee; Chang Duk Jun; Byung Ju Choi; Sang Yong Kim; Sug Hyun Kim; Dae Keun Kim; Jeong Suk Park; Byeong Suk Chae; Tae Yong Shin

doi:10.1016/j.intimp.2005.06.007

The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion

Sang Hyun Kim, Hyo Hyun Park, Soyoung Lee, Chang Duk Jun, Byung Ju Choi, Sang Yong Kim, Sug Hyun Kim, Dae Keun Kim, Jeong Suk Park, Byeong Suk Chae, Tae Yong Shin

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Abstract

The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. We investigated the effect of the gall of Rhus javanica (GRJ) on the model of the immediate-type allergic reaction, and studied its possible mechanisms. GRJ inhibited compound 48/80-induced systemic reactions in mice. GRJ attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, GRJ dose dependently decreased histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. The decreasing effect of GRJ on the histamine release was mediated by the modulation of cAMP and [Ca²⁺]i in mast cells. Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-α and IL-6 secretion in human mast cells. The inhibitory effect of GRJ on the pro-inflammatory cytokine was c-Jun N-terminal kinase and nuclear factor-κB dependent. Our findings provide evidence that GRJ inhibits mast cell-derived immediate-type allergic reactions, and suggest the possible mechanisms of action.

Original language	English
Pages (from-to)	1820-1829
Number of pages	10
Journal	International Immunopharmacology
Volume	5
Issue number	13-14
DOIs	https://doi.org/10.1016/j.intimp.2005.06.007
State	Published - Dec 2005

Keywords

Allergic reaction
cAMP
Gall of Rhus javanica
Histamine
Inflammatory cytokine. c-Jun N-terminal kinase
Intracellular calcium
Mast cell
Nuclear factor-κB

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Kim, S. H., Park, H. H., Lee, S., Jun, C. D., Choi, B. J., Kim, S. Y., Kim, S. H., Kim, D. K., Park, J. S., Chae, B. S., & Shin, T. Y. (2005). The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion. International Immunopharmacology, 5(13-14), 1820-1829. https://doi.org/10.1016/j.intimp.2005.06.007

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title = "The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion",

abstract = "The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. We investigated the effect of the gall of Rhus javanica (GRJ) on the model of the immediate-type allergic reaction, and studied its possible mechanisms. GRJ inhibited compound 48/80-induced systemic reactions in mice. GRJ attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, GRJ dose dependently decreased histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. The decreasing effect of GRJ on the histamine release was mediated by the modulation of cAMP and [Ca2+]i in mast cells. Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-α and IL-6 secretion in human mast cells. The inhibitory effect of GRJ on the pro-inflammatory cytokine was c-Jun N-terminal kinase and nuclear factor-κB dependent. Our findings provide evidence that GRJ inhibits mast cell-derived immediate-type allergic reactions, and suggest the possible mechanisms of action.",

keywords = "Allergic reaction, cAMP, Gall of Rhus javanica, Histamine, Inflammatory cytokine. c-Jun N-terminal kinase, Intracellular calcium, Mast cell, Nuclear factor-κB",

author = "Kim, {Sang Hyun} and Park, {Hyo Hyun} and Soyoung Lee and Jun, {Chang Duk} and Choi, {Byung Ju} and Kim, {Sang Yong} and Kim, {Sug Hyun} and Kim, {Dae Keun} and Park, {Jeong Suk} and Chae, {Byeong Suk} and Shin, {Tae Yong}",

year = "2005",

month = dec,

doi = "10.1016/j.intimp.2005.06.007",

language = "English",

volume = "5",

pages = "1820--1829",

journal = "International Immunopharmacology",

issn = "1567-5769",

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}

Kim, SH, Park, HH, Lee, S, Jun, CD, Choi, BJ, Kim, SY, Kim, SH, Kim, DK, Park, JS, Chae, BS & Shin, TY 2005, 'The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion', International Immunopharmacology, vol. 5, no. 13-14, pp. 1820-1829. https://doi.org/10.1016/j.intimp.2005.06.007

TY - JOUR

T1 - The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion

AU - Kim, Sang Hyun

AU - Park, Hyo Hyun

AU - Lee, Soyoung

AU - Jun, Chang Duk

AU - Choi, Byung Ju

AU - Kim, Sang Yong

AU - Kim, Sug Hyun

AU - Kim, Dae Keun

AU - Park, Jeong Suk

AU - Chae, Byeong Suk

AU - Shin, Tae Yong

PY - 2005/12

Y1 - 2005/12

N2 - The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. We investigated the effect of the gall of Rhus javanica (GRJ) on the model of the immediate-type allergic reaction, and studied its possible mechanisms. GRJ inhibited compound 48/80-induced systemic reactions in mice. GRJ attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, GRJ dose dependently decreased histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. The decreasing effect of GRJ on the histamine release was mediated by the modulation of cAMP and [Ca2+]i in mast cells. Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-α and IL-6 secretion in human mast cells. The inhibitory effect of GRJ on the pro-inflammatory cytokine was c-Jun N-terminal kinase and nuclear factor-κB dependent. Our findings provide evidence that GRJ inhibits mast cell-derived immediate-type allergic reactions, and suggest the possible mechanisms of action.

AB - The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. We investigated the effect of the gall of Rhus javanica (GRJ) on the model of the immediate-type allergic reaction, and studied its possible mechanisms. GRJ inhibited compound 48/80-induced systemic reactions in mice. GRJ attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, GRJ dose dependently decreased histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. The decreasing effect of GRJ on the histamine release was mediated by the modulation of cAMP and [Ca2+]i in mast cells. Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-α and IL-6 secretion in human mast cells. The inhibitory effect of GRJ on the pro-inflammatory cytokine was c-Jun N-terminal kinase and nuclear factor-κB dependent. Our findings provide evidence that GRJ inhibits mast cell-derived immediate-type allergic reactions, and suggest the possible mechanisms of action.

KW - Allergic reaction

KW - cAMP

KW - Gall of Rhus javanica

KW - Histamine

KW - Inflammatory cytokine. c-Jun N-terminal kinase

KW - Intracellular calcium

KW - Mast cell

KW - Nuclear factor-κB

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U2 - 10.1016/j.intimp.2005.06.007

DO - 10.1016/j.intimp.2005.06.007

M3 - Article

C2 - 16275618

AN - SCOPUS:27744548780

SN - 1567-5769

VL - 5

SP - 1820

EP - 1829

JO - International Immunopharmacology

JF - International Immunopharmacology

IS - 13-14

ER -

The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion

Abstract

Keywords

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