The antitumor natural compound falcarindiol disrupts neural stem cell homeostasis by suppressing notch pathway

Tae Jun Kim, Hyun Sook Kwon, Mingyu Kang, Hyun Hee Leem, Kyung Ha Lee, Do Yeon Kim

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional neurons and glial cells. The disruption in NSC homeostasis and/or the impaired neurogenesis lead to diverse neurological diseases, including depression, dementia, and neurodegenerative disorders. Falcarindiol (FAD) is a polyacetylene found in many plants, and FAD shows the cytotoxicity against breast cancers and colon cancers. However, there is no research on the consequence of FAD treatment in normal stem cells. Here, we suggest that FAD has anticancer roles against glioblastoma cells by inducing the differentiation of glioblastoma stem-like cells, as well as activating apoptosis pathway in glioblastoma cells. On the other hand, we also show that FAD has detrimental effects by disrupting the maintenance of normal NSCs and altering the balance between self-renewal and differentiation of NSCs.

Original languageEnglish
Article number3432
JournalInternational Journal of Molecular Sciences
Volume19
Issue number11
DOIs
StatePublished - 1 Nov 2018

Keywords

  • Apoptosis
  • Differentiation
  • Falcarindiol
  • Neural stem cell
  • Notch pathway

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