The dual binding site of angiogenin and its inhibition mechanism: The crystal structure of the rat angiogenin-heparin complex

Kwon Joo Yeo; Eunha Hwang; Kyong Mi Min; Jun Goo Jee; Chung Kyung Lee; Kwang Yeon Hwang; Young Ho Jeon; Soo Ik Chang; Hae Kap Cheong

doi:10.1039/c4cc05175k

The dual binding site of angiogenin and its inhibition mechanism: The crystal structure of the rat angiogenin-heparin complex

Kwon Joo Yeo, Eunha Hwang, Kyong Mi Min, Jun Goo Jee, Chung Kyung Lee, Kwang Yeon Hwang, Young Ho Jeon, Soo Ik Chang, Hae Kap Cheong

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Abstract

The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.

Original language	English
Pages (from-to)	12966-12969
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	85
DOIs	https://doi.org/10.1039/c4cc05175k
State	Published - 30 Sep 2014

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title = "The dual binding site of angiogenin and its inhibition mechanism: The crystal structure of the rat angiogenin-heparin complex",

abstract = "The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.",

author = "{Joo Yeo}, Kwon and Eunha Hwang and Min, {Kyong Mi} and Jee, {Jun Goo} and Lee, {Chung Kyung} and Hwang, {Kwang Yeon} and Jeon, {Young Ho} and Chang, {Soo Ik} and Cheong, {Hae Kap}",

year = "2014",

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doi = "10.1039/c4cc05175k",

language = "English",

volume = "50",

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T1 - The dual binding site of angiogenin and its inhibition mechanism

T2 - The crystal structure of the rat angiogenin-heparin complex

AU - Joo Yeo, Kwon

AU - Hwang, Eunha

AU - Min, Kyong Mi

AU - Jee, Jun Goo

AU - Lee, Chung Kyung

AU - Hwang, Kwang Yeon

AU - Jeon, Young Ho

AU - Chang, Soo Ik

AU - Cheong, Hae Kap

PY - 2014/9/30

Y1 - 2014/9/30

N2 - The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.

AB - The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.

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U2 - 10.1039/c4cc05175k

DO - 10.1039/c4cc05175k

M3 - Article

C2 - 25219815

AN - SCOPUS:84907626248

SN - 1359-7345

VL - 50

SP - 12966

EP - 12969

JO - Chemical Communications

JF - Chemical Communications

IS - 85

ER -

The dual binding site of angiogenin and its inhibition mechanism: The crystal structure of the rat angiogenin-heparin complex

Abstract

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