The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts

Song Yi Lee; Mi Ran Kim; Hong Seok Choi; Hyung In Moon; Jin Ho Chung; Dong Gun Lee; Eun Rhan Woo

doi:10.1007/s12272-009-2013-4

The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts

Song Yi Lee, Mi Ran Kim, Hong Seok Choi, Hyung In Moon, Jin Ho Chung, Dong Gun Lee, Eun Rhan Woo

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24 Scopus citations

Abstract

The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-β-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.

Original language	English
Pages (from-to)	1433-1439
Number of pages	7
Journal	Archives of Pharmacal Research
Volume	32
Issue number	10
DOIs	https://doi.org/10.1007/s12272-009-2013-4
State	Published - Oct 2009

Keywords

Amaryllidaceae
Curculigo orchioides G.
Curculigoside
Cycloartane saponin
Matrix metalloproteinase-1
Phenolic glycoside
Type-1 procollagen

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title = "The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts",

abstract = "The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-β-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.",

keywords = "Amaryllidaceae, Curculigo orchioides G., Curculigoside, Cycloartane saponin, Matrix metalloproteinase-1, Phenolic glycoside, Type-1 procollagen",

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T1 - The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts

AU - Lee, Song Yi

AU - Kim, Mi Ran

AU - Choi, Hong Seok

AU - Moon, Hyung In

AU - Chung, Jin Ho

AU - Lee, Dong Gun

AU - Woo, Eun Rhan

PY - 2009/10

Y1 - 2009/10

N2 - The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-β-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.

AB - The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-β-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.

KW - Amaryllidaceae

KW - Curculigo orchioides G.

KW - Curculigoside

KW - Cycloartane saponin

KW - Matrix metalloproteinase-1

KW - Phenolic glycoside

KW - Type-1 procollagen

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U2 - 10.1007/s12272-009-2013-4

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SN - 0253-6269

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JO - Archives of Pharmacal Research

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The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts

Abstract

Keywords

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