The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression

Xiang Mei Yan; Min Jae Joo; Jae Chun Lim; Wan Kyun Whang; Sang Soo Sim; Chaeuk Im; Hak Rim Kim; Seok Yong Lee; In Kyeom Kim; Uy Dong Sohn

doi:10.1007/s12272-011-0915-4

The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression

Xiang Mei Yan, Min Jae Joo, Jae Chun Lim, Wan Kyun Whang, Sang Soo Sim, Chaeuk Im, Hak Rim Kim, Seok Yong Lee, In Kyeom Kim, Uy Dong Sohn

Department of Medicine

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32 Scopus citations

Abstract

The mechanism of the protective effect of quercetin-3-O-β-D- glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated. Pre-treatment with QGC significantly attenuated IND-induced gastric mucosal injury. An increase in myeloperoxidase (MPO) activity and expression of intercellular adhesion molecule (ICAM)-1 protein and mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β, as well as a decrease in gastric mucus secretion were detected in the gastric mucosa of IND-treated rats. QGC reversed the side effect of IND on MPO activity and mucus production. Furthermore, QGC pre-treatment notably decreased ICAM-1 protein and mRNA expression of the pro-inflammatory cytokines, suggesting that QGC protection from IND-induced damage is associated with increased gastric mucus secretion, inhibition of free radical production by activated neutrophils via ICAM-1, and pro-inflammatory cytokine downregulation.

Original language	English
Pages (from-to)	1527-1534
Number of pages	8
Journal	Archives of Pharmacal Research
Volume	34
Issue number	9
DOIs	https://doi.org/10.1007/s12272-011-0915-4
State	Published - Sep 2011

Keywords

Gastric damage
Intercellular adhesion molecule-1
Interleukin-1β
Mucus secretion
Myeloperoxidase
Quercetin-3-O-β-D-glucuronopyranoside
Tumor necrosis factor-α

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Yan, X. M., Joo, M. J., Lim, J. C., Whang, W. K., Sim, S. S., Im, C., Kim, H. R., Lee, S. Y., Kim, I. K., & Sohn, U. D. (2011). The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression. Archives of Pharmacal Research, 34(9), 1527-1534. https://doi.org/10.1007/s12272-011-0915-4

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title = "The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression",

abstract = "The mechanism of the protective effect of quercetin-3-O-β-D- glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated. Pre-treatment with QGC significantly attenuated IND-induced gastric mucosal injury. An increase in myeloperoxidase (MPO) activity and expression of intercellular adhesion molecule (ICAM)-1 protein and mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β, as well as a decrease in gastric mucus secretion were detected in the gastric mucosa of IND-treated rats. QGC reversed the side effect of IND on MPO activity and mucus production. Furthermore, QGC pre-treatment notably decreased ICAM-1 protein and mRNA expression of the pro-inflammatory cytokines, suggesting that QGC protection from IND-induced damage is associated with increased gastric mucus secretion, inhibition of free radical production by activated neutrophils via ICAM-1, and pro-inflammatory cytokine downregulation.",

keywords = "Gastric damage, Intercellular adhesion molecule-1, Interleukin-1β, Mucus secretion, Myeloperoxidase, Quercetin-3-O-β-D-glucuronopyranoside, Tumor necrosis factor-α",

author = "Yan, {Xiang Mei} and Joo, {Min Jae} and Lim, {Jae Chun} and Whang, {Wan Kyun} and Sim, {Sang Soo} and Chaeuk Im and Kim, {Hak Rim} and Lee, {Seok Yong} and Kim, {In Kyeom} and Sohn, {Uy Dong}",

year = "2011",

month = sep,

doi = "10.1007/s12272-011-0915-4",

language = "English",

volume = "34",

pages = "1527--1534",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

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Yan, XM, Joo, MJ, Lim, JC, Whang, WK, Sim, SS, Im, C, Kim, HR, Lee, SY, Kim, IK & Sohn, UD 2011, 'The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression', Archives of Pharmacal Research, vol. 34, no. 9, pp. 1527-1534. https://doi.org/10.1007/s12272-011-0915-4

The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression. / Yan, Xiang Mei; Joo, Min Jae; Lim, Jae Chun et al.
In: Archives of Pharmacal Research, Vol. 34, No. 9, 09.2011, p. 1527-1534.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression

AU - Yan, Xiang Mei

AU - Joo, Min Jae

AU - Lim, Jae Chun

AU - Whang, Wan Kyun

AU - Sim, Sang Soo

AU - Im, Chaeuk

AU - Kim, Hak Rim

AU - Lee, Seok Yong

AU - Kim, In Kyeom

AU - Sohn, Uy Dong

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N2 - The mechanism of the protective effect of quercetin-3-O-β-D- glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated. Pre-treatment with QGC significantly attenuated IND-induced gastric mucosal injury. An increase in myeloperoxidase (MPO) activity and expression of intercellular adhesion molecule (ICAM)-1 protein and mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β, as well as a decrease in gastric mucus secretion were detected in the gastric mucosa of IND-treated rats. QGC reversed the side effect of IND on MPO activity and mucus production. Furthermore, QGC pre-treatment notably decreased ICAM-1 protein and mRNA expression of the pro-inflammatory cytokines, suggesting that QGC protection from IND-induced damage is associated with increased gastric mucus secretion, inhibition of free radical production by activated neutrophils via ICAM-1, and pro-inflammatory cytokine downregulation.

AB - The mechanism of the protective effect of quercetin-3-O-β-D- glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated. Pre-treatment with QGC significantly attenuated IND-induced gastric mucosal injury. An increase in myeloperoxidase (MPO) activity and expression of intercellular adhesion molecule (ICAM)-1 protein and mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β, as well as a decrease in gastric mucus secretion were detected in the gastric mucosa of IND-treated rats. QGC reversed the side effect of IND on MPO activity and mucus production. Furthermore, QGC pre-treatment notably decreased ICAM-1 protein and mRNA expression of the pro-inflammatory cytokines, suggesting that QGC protection from IND-induced damage is associated with increased gastric mucus secretion, inhibition of free radical production by activated neutrophils via ICAM-1, and pro-inflammatory cytokine downregulation.

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KW - Intercellular adhesion molecule-1

KW - Interleukin-1β

KW - Mucus secretion

KW - Myeloperoxidase

KW - Quercetin-3-O-β-D-glucuronopyranoside

KW - Tumor necrosis factor-α

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U2 - 10.1007/s12272-011-0915-4

DO - 10.1007/s12272-011-0915-4

M3 - Article

C2 - 21975815

AN - SCOPUS:80755142686

SN - 0253-6269

VL - 34

SP - 1527

EP - 1534

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 9

ER -

The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression

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