TY - JOUR
T1 - The emerging role of exosomes in innate immunity, diagnosis and therapy
AU - Gangadaran, Prakash
AU - Madhyastha, Harishkumar
AU - Madhyastha, Radha
AU - Rajendran, Ramya Lakshmi
AU - Nakajima, Yuichi
AU - Watanabe, Nozomi
AU - Velikkakath, Anoop Kumar G.
AU - Hong, Chae Moon
AU - Gopi, Rahul Velikkakath
AU - Muthukalianan, Gothandam Kodiveri
AU - Valsala Gopalakrishnan, Abilash
AU - Jeyaraman, Madhan
AU - Ahn, Byeong Cheol
N1 - Publisher Copyright:
Copyright © 2023 Gangadaran, Madhyastha, Madhyastha, Rajendran, Nakajima, Watanabe, Velikkakath, Hong, Gopi, Muthukalianan, Valsala Gopalakrishnan, Jeyaraman and Ahn.
PY - 2023/1/16
Y1 - 2023/1/16
N2 - Exosomes, which are nano-sized transport bio-vehicles, play a pivotal role in maintaining homeostasis by exchanging genetic or metabolic information between different cells. Exosomes can also play a vital role in transferring virulent factors between the host and parasite, thereby regulating host gene expression and the immune interphase. The association of inflammation with disease development and the potential of exosomes to enhance or mitigate inflammatory pathways support the notion that exosomes have the potential to alter the course of a disease. Clinical trials exploring the role of exosomes in cancer, osteoporosis, and renal, neurological, and pulmonary disorders are currently underway. Notably, the information available on the signatory efficacy of exosomes in immune-related disorders remains elusive and sporadic. In this review, we discuss immune cell-derived exosomes and their application in immunotherapy, including those against autoimmune connective tissue diseases. Further, we have elucidated our views on the major issues in immune-related pathophysiological processes. Therefore, the information presented in this review highlights the role of exosomes as promising strategies and clinical tools for immune regulation.
AB - Exosomes, which are nano-sized transport bio-vehicles, play a pivotal role in maintaining homeostasis by exchanging genetic or metabolic information between different cells. Exosomes can also play a vital role in transferring virulent factors between the host and parasite, thereby regulating host gene expression and the immune interphase. The association of inflammation with disease development and the potential of exosomes to enhance or mitigate inflammatory pathways support the notion that exosomes have the potential to alter the course of a disease. Clinical trials exploring the role of exosomes in cancer, osteoporosis, and renal, neurological, and pulmonary disorders are currently underway. Notably, the information available on the signatory efficacy of exosomes in immune-related disorders remains elusive and sporadic. In this review, we discuss immune cell-derived exosomes and their application in immunotherapy, including those against autoimmune connective tissue diseases. Further, we have elucidated our views on the major issues in immune-related pathophysiological processes. Therefore, the information presented in this review highlights the role of exosomes as promising strategies and clinical tools for immune regulation.
KW - circulation
KW - exosomes
KW - secretory cells
KW - therapy
KW - tissue inflammation
UR - http://www.scopus.com/inward/record.url?scp=85147144397&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2022.1085057
DO - 10.3389/fimmu.2022.1085057
M3 - Review article
C2 - 36726968
AN - SCOPUS:85147144397
SN - 1664-3224
VL - 13
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1085057
ER -
