The in vitro and in vivo safety evaluation of lactobacillus acidophilus IDCC 3302

Won Yeong Bang; Seung A. Chae; O. Hyun Ban; Sangki Oh; Chanmi Park; Minjee Lee; Minhye Shin; Jungwoo Yang; Young Hoon Jung

doi:10.48022/MBL.2011.11004

The in vitro and in vivo safety evaluation of lactobacillus acidophilus IDCC 3302

Won Yeong Bang, Seung A. Chae, O. Hyun Ban, Sangki Oh, Chanmi Park, Minjee Lee, Minhye Shin, Jungwoo Yang, Young Hoon Jung

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

As consumption of healthy foods continues to garner remarkable public attention, ensuring probiotic safety has become a priority. In this study, the safety of Lactobacillus acidophilus IDCC 3302 was assessed in vitro and in vivo. L. acidophilus IDCC 3302 showed negative results for hemolytic and β-glucuronidase activities. The whole-genome analysis (WGA) revealed that L. acidophilus IDCC 3302 did not possess antibiotic resistance or virulence genes. The minimal inhibitory concentrations of L. acidophilus IDCC 3302 confirmed its safety concerning antibiotic resistance. Furthermore, L. acidophilus IDCC 3302 was demonstrated to be nontoxic in the oral toxicity test in rats. Therefore, the results suggested that L. acidophilus IDCC 3302 might be safe for human consumption.

Original language	English
Pages (from-to)	39-44
Number of pages	6
Journal	Microbiology and Biotechnology Letters
Volume	49
Issue number	1
DOIs	https://doi.org/10.48022/MBL.2011.11004
State	Published - 1 Mar 2021

Keywords

Antibiotic resistance
Lactobacillus acidophilus
Probiotics
Safety evaluation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.48022/MBL.2011.11004

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abstract = "As consumption of healthy foods continues to garner remarkable public attention, ensuring probiotic safety has become a priority. In this study, the safety of Lactobacillus acidophilus IDCC 3302 was assessed in vitro and in vivo. L. acidophilus IDCC 3302 showed negative results for hemolytic and β-glucuronidase activities. The whole-genome analysis (WGA) revealed that L. acidophilus IDCC 3302 did not possess antibiotic resistance or virulence genes. The minimal inhibitory concentrations of L. acidophilus IDCC 3302 confirmed its safety concerning antibiotic resistance. Furthermore, L. acidophilus IDCC 3302 was demonstrated to be nontoxic in the oral toxicity test in rats. Therefore, the results suggested that L. acidophilus IDCC 3302 might be safe for human consumption.",

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AU - Chae, Seung A.

AU - Ban, O. Hyun

AU - Oh, Sangki

AU - Park, Chanmi

AU - Lee, Minjee

AU - Shin, Minhye

AU - Yang, Jungwoo

AU - Jung, Young Hoon

PY - 2021/3/1

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AB - As consumption of healthy foods continues to garner remarkable public attention, ensuring probiotic safety has become a priority. In this study, the safety of Lactobacillus acidophilus IDCC 3302 was assessed in vitro and in vivo. L. acidophilus IDCC 3302 showed negative results for hemolytic and β-glucuronidase activities. The whole-genome analysis (WGA) revealed that L. acidophilus IDCC 3302 did not possess antibiotic resistance or virulence genes. The minimal inhibitory concentrations of L. acidophilus IDCC 3302 confirmed its safety concerning antibiotic resistance. Furthermore, L. acidophilus IDCC 3302 was demonstrated to be nontoxic in the oral toxicity test in rats. Therefore, the results suggested that L. acidophilus IDCC 3302 might be safe for human consumption.

KW - Antibiotic resistance

KW - Lactobacillus acidophilus

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KW - Safety evaluation

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The in vitro and in vivo safety evaluation of lactobacillus acidophilus IDCC 3302

Abstract

Keywords

UN SDGs

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