The JAK/STAT Pathway Is Involved in Synaptic Plasticity

Céline S. Nicolas; Stéphane Peineau; Mascia Amici; Zsolt Csaba; Assia Fafouri; Charlotte Javalet; Valerie J. Collett; Lars Hildebrandt; Gillian Seaton; Sun Lim Choi; Su Eon Sim; Clarrisa Bradley; Kyungmin Lee; Min Zhuo; Bong Kiun Kaang; Pierre Gressens; Pascal Dournaud; Stephen M. Fitzjohn; Zuner A. Bortolotto; Kwangwook Cho; Graham L. Collingridge

doi:10.1016/j.neuron.2011.11.024

The JAK/STAT Pathway Is Involved in Synaptic Plasticity

Céline S. Nicolas, Stéphane Peineau, Mascia Amici, Zsolt Csaba, Assia Fafouri, Charlotte Javalet, Valerie J. Collett, Lars Hildebrandt, Gillian Seaton, Sun Lim Choi, Su Eon Sim, Clarrisa Bradley, Kyungmin Lee, Min Zhuo, Bong Kiun Kaang, Pierre Gressens, Pascal Dournaud, Stephen M. Fitzjohn, Zuner A. Bortolotto, Kwangwook ChoGraham L. Collingridge

Department of Medicine

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain. The authors demonstrate a new neuronal function for the JAK/STAT pathway in the induction of NMDA-receptor-dependent long-term depression (NMDAR-LTD) in the hippocampus.

Original language	English
Pages (from-to)	374-390
Number of pages	17
Journal	Neuron
Volume	73
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2011.11.024
State	Published - 26 Jan 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.neuron.2011.11.024

Cite this

Nicolas, C. S., Peineau, S., Amici, M., Csaba, Z., Fafouri, A., Javalet, C., Collett, V. J., Hildebrandt, L., Seaton, G., Choi, S. L., Sim, S. E., Bradley, C., Lee, K., Zhuo, M., Kaang, B. K., Gressens, P., Dournaud, P., Fitzjohn, S. M., Bortolotto, Z. A., ... Collingridge, G. L. (2012). The JAK/STAT Pathway Is Involved in Synaptic Plasticity. Neuron, 73(2), 374-390. https://doi.org/10.1016/j.neuron.2011.11.024

@article{1514c23dad8d4458abce2b9acd8a0294,

title = "The JAK/STAT Pathway Is Involved in Synaptic Plasticity",

abstract = "The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain. The authors demonstrate a new neuronal function for the JAK/STAT pathway in the induction of NMDA-receptor-dependent long-term depression (NMDAR-LTD) in the hippocampus.",

author = "Nicolas, {C{\'e}line S.} and St{\'e}phane Peineau and Mascia Amici and Zsolt Csaba and Assia Fafouri and Charlotte Javalet and Collett, {Valerie J.} and Lars Hildebrandt and Gillian Seaton and Choi, {Sun Lim} and Sim, {Su Eon} and Clarrisa Bradley and Kyungmin Lee and Min Zhuo and Kaang, {Bong Kiun} and Pierre Gressens and Pascal Dournaud and Fitzjohn, {Stephen M.} and Bortolotto, {Zuner A.} and Kwangwook Cho and Collingridge, {Graham L.}",

year = "2012",

month = jan,

day = "26",

doi = "10.1016/j.neuron.2011.11.024",

language = "English",

volume = "73",

pages = "374--390",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "2",

}

Nicolas, CS, Peineau, S, Amici, M, Csaba, Z, Fafouri, A, Javalet, C, Collett, VJ, Hildebrandt, L, Seaton, G, Choi, SL, Sim, SE, Bradley, C, Lee, K, Zhuo, M, Kaang, BK, Gressens, P, Dournaud, P, Fitzjohn, SM, Bortolotto, ZA, Cho, K & Collingridge, GL 2012, 'The JAK/STAT Pathway Is Involved in Synaptic Plasticity', Neuron, vol. 73, no. 2, pp. 374-390. https://doi.org/10.1016/j.neuron.2011.11.024

TY - JOUR

T1 - The JAK/STAT Pathway Is Involved in Synaptic Plasticity

AU - Nicolas, Céline S.

AU - Peineau, Stéphane

AU - Amici, Mascia

AU - Csaba, Zsolt

AU - Fafouri, Assia

AU - Javalet, Charlotte

AU - Collett, Valerie J.

AU - Hildebrandt, Lars

AU - Seaton, Gillian

AU - Choi, Sun Lim

AU - Sim, Su Eon

AU - Bradley, Clarrisa

AU - Lee, Kyungmin

AU - Zhuo, Min

AU - Kaang, Bong Kiun

AU - Gressens, Pierre

AU - Dournaud, Pascal

AU - Fitzjohn, Stephen M.

AU - Bortolotto, Zuner A.

AU - Cho, Kwangwook

AU - Collingridge, Graham L.

PY - 2012/1/26

Y1 - 2012/1/26

N2 - The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain. The authors demonstrate a new neuronal function for the JAK/STAT pathway in the induction of NMDA-receptor-dependent long-term depression (NMDAR-LTD) in the hippocampus.

AB - The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain. The authors demonstrate a new neuronal function for the JAK/STAT pathway in the induction of NMDA-receptor-dependent long-term depression (NMDAR-LTD) in the hippocampus.

UR - http://www.scopus.com/inward/record.url?scp=84863012554&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2011.11.024

DO - 10.1016/j.neuron.2011.11.024

M3 - Article

C2 - 22284190

AN - SCOPUS:84863012554

SN - 0896-6273

VL - 73

SP - 374

EP - 390

JO - Neuron

JF - Neuron

IS - 2

ER -

The JAK/STAT Pathway Is Involved in Synaptic Plasticity

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this