The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase

Jae Ho Shin; Young Heo Gun; Zvi Kelman

doi:10.1128/JB.00233-08

The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase

Jae Ho Shin
, Young Heo Gun
, Zvi Kelman

University of Maryland, College Park

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The Cdc6-1 and -2 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind the minichromosome maintenance (MCM) helicase. It is shown here that Cdc6-2 protein dissociates the MCM complex. This observation supports the hypothesis that the Cdc6-2 protein functions as a helicase loader.

Original language	English
Pages (from-to)	4091-4094
Number of pages	4
Journal	Journal of Bacteriology
Volume	190
Issue number	11
DOIs	https://doi.org/10.1128/JB.00233-08
State	Published - Jun 2008

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title = "The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase",

abstract = "The Cdc6-1 and -2 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind the minichromosome maintenance (MCM) helicase. It is shown here that Cdc6-2 protein dissociates the MCM complex. This observation supports the hypothesis that the Cdc6-2 protein functions as a helicase loader.",

author = "Shin, \{Jae Ho\} and Gun, \{Young Heo\} and Zvi Kelman",

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T1 - The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase

AU - Shin, Jae Ho

AU - Gun, Young Heo

AU - Kelman, Zvi

PY - 2008/6

Y1 - 2008/6

N2 - The Cdc6-1 and -2 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind the minichromosome maintenance (MCM) helicase. It is shown here that Cdc6-2 protein dissociates the MCM complex. This observation supports the hypothesis that the Cdc6-2 protein functions as a helicase loader.

AB - The Cdc6-1 and -2 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind the minichromosome maintenance (MCM) helicase. It is shown here that Cdc6-2 protein dissociates the MCM complex. This observation supports the hypothesis that the Cdc6-2 protein functions as a helicase loader.

UR - https://www.scopus.com/pages/publications/44349119246

U2 - 10.1128/JB.00233-08

DO - 10.1128/JB.00233-08

M3 - Article

C2 - 18390662

AN - SCOPUS:44349119246

SN - 0021-9193

VL - 190

SP - 4091

EP - 4094

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 11

ER -

The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase

Abstract

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