The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer

Kyung Min Shin; Deuk Kju Jung; Mi Jeong Hong; Hyo Jung Kang; Won Kee Lee; Seung Soo Yoo; Shin Yup Lee; Seung Ick Cha; Jaehee Lee; Chang Ho Kim; Yangki Seok; Sukki Cho; Ji Woong Son; Eung Bae Lee; Sanghoon Jheon; Young Tae Kim; Jae Yong Park

doi:10.1016/j.gene.2015.11.036

The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer

Kyung Min Shin, Deuk Kju Jung, Mi Jeong Hong, Hyo Jung Kang, Won Kee Lee, Seung Soo Yoo, Shin Yup Lee, Seung Ick Cha, Jaehee Lee, Chang Ho Kim, Yangki Seok, Sukki Cho, Ji Woong Son, Eung Bae Lee, Sanghoon Jheon, Young Tae Kim, Jae Yong Park

Department of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: Evidence indicates that let-7 of microRNA may be a prognostic factor in lung cancer. Genetic variation in microRNA precursors could influence the processing and expression of microRNAs, which could affect the prognosis of lung cancer. We aimed to investigate the impact of single nucleotide polymorphisms (SNPs) of pri-let-7 on the prognosis of non-small cell lung cancer (NSCLC). Method: A total of 761 patients with surgically resected NSCLC were included. Four SNPs (pri-let-7a-2 rs1143770 and rs629367, pri-let-7a-1 rs10739971, and pri-let-7f-2 rs17276588) were genotyped using sequenom mass spectrometry-based genotyping assay. Overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier method and Cox proportional hazards model. Results: Of the 4 SNPs evaluated, the rs1143770C. >. T was found to be significantly associated with OS and DFS. The rs1143770 CT or TT genotype exhibited a significantly better OS and DFS compared with the rs1143770 CC genotype (adjusted hazard ratio for OS = 0.67, confidence interval, 0.49-0.91, P= 0.01 and adjusted hazard ratio for DFS = 0.74, confidence interval, 0.58-0.95, P= 0.02). Conclusion: This observation indicates that pri-let-7a-2 rs1143770C. >. T may have a prognostic impact on surgically resected NSCLC.

Original language	English
Pages (from-to)	148-152
Number of pages	5
Journal	Gene
Volume	577
Issue number	2
DOIs	https://doi.org/10.1016/j.gene.2015.11.036
State	Published - 15 Feb 2016

Keywords

Let-7
Lung cancer
MicroRNA
Risk factor
SNP

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.gene.2015.11.036

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Shin, K. M., Jung, D. K., Hong, M. J., Kang, H. J., Lee, W. K., Yoo, S. S., Lee, S. Y., Cha, S. I., Lee, J., Kim, C. H., Seok, Y., Cho, S., Son, J. W., Lee, E. B., Jheon, S., Kim, Y. T., & Park, J. Y. (2016). The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer. Gene, 577(2), 148-152. https://doi.org/10.1016/j.gene.2015.11.036

@article{90ab7a6738ca4ed1884f58b17e8320e6,

title = "The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer",

abstract = "Background: Evidence indicates that let-7 of microRNA may be a prognostic factor in lung cancer. Genetic variation in microRNA precursors could influence the processing and expression of microRNAs, which could affect the prognosis of lung cancer. We aimed to investigate the impact of single nucleotide polymorphisms (SNPs) of pri-let-7 on the prognosis of non-small cell lung cancer (NSCLC). Method: A total of 761 patients with surgically resected NSCLC were included. Four SNPs (pri-let-7a-2 rs1143770 and rs629367, pri-let-7a-1 rs10739971, and pri-let-7f-2 rs17276588) were genotyped using sequenom mass spectrometry-based genotyping assay. Overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier method and Cox proportional hazards model. Results: Of the 4 SNPs evaluated, the rs1143770C. >. T was found to be significantly associated with OS and DFS. The rs1143770 CT or TT genotype exhibited a significantly better OS and DFS compared with the rs1143770 CC genotype (adjusted hazard ratio for OS = 0.67, confidence interval, 0.49-0.91, P= 0.01 and adjusted hazard ratio for DFS = 0.74, confidence interval, 0.58-0.95, P= 0.02). Conclusion: This observation indicates that pri-let-7a-2 rs1143770C. >. T may have a prognostic impact on surgically resected NSCLC.",

keywords = "Let-7, Lung cancer, MicroRNA, Risk factor, SNP",

author = "Shin, {Kyung Min} and Jung, {Deuk Kju} and Hong, {Mi Jeong} and Kang, {Hyo Jung} and Lee, {Won Kee} and Yoo, {Seung Soo} and Lee, {Shin Yup} and Cha, {Seung Ick} and Jaehee Lee and Kim, {Chang Ho} and Yangki Seok and Sukki Cho and Son, {Ji Woong} and Lee, {Eung Bae} and Sanghoon Jheon and Kim, {Young Tae} and Park, {Jae Yong}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2016",

month = feb,

day = "15",

doi = "10.1016/j.gene.2015.11.036",

language = "English",

volume = "577",

pages = "148--152",

journal = "Gene",

issn = "0378-1119",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer

AU - Shin, Kyung Min

AU - Jung, Deuk Kju

AU - Hong, Mi Jeong

AU - Kang, Hyo Jung

AU - Lee, Won Kee

AU - Yoo, Seung Soo

AU - Lee, Shin Yup

AU - Cha, Seung Ick

AU - Lee, Jaehee

AU - Kim, Chang Ho

AU - Seok, Yangki

AU - Cho, Sukki

AU - Son, Ji Woong

AU - Lee, Eung Bae

AU - Jheon, Sanghoon

AU - Kim, Young Tae

AU - Park, Jae Yong

PY - 2016/2/15

Y1 - 2016/2/15

N2 - Background: Evidence indicates that let-7 of microRNA may be a prognostic factor in lung cancer. Genetic variation in microRNA precursors could influence the processing and expression of microRNAs, which could affect the prognosis of lung cancer. We aimed to investigate the impact of single nucleotide polymorphisms (SNPs) of pri-let-7 on the prognosis of non-small cell lung cancer (NSCLC). Method: A total of 761 patients with surgically resected NSCLC were included. Four SNPs (pri-let-7a-2 rs1143770 and rs629367, pri-let-7a-1 rs10739971, and pri-let-7f-2 rs17276588) were genotyped using sequenom mass spectrometry-based genotyping assay. Overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier method and Cox proportional hazards model. Results: Of the 4 SNPs evaluated, the rs1143770C. >. T was found to be significantly associated with OS and DFS. The rs1143770 CT or TT genotype exhibited a significantly better OS and DFS compared with the rs1143770 CC genotype (adjusted hazard ratio for OS = 0.67, confidence interval, 0.49-0.91, P= 0.01 and adjusted hazard ratio for DFS = 0.74, confidence interval, 0.58-0.95, P= 0.02). Conclusion: This observation indicates that pri-let-7a-2 rs1143770C. >. T may have a prognostic impact on surgically resected NSCLC.

AB - Background: Evidence indicates that let-7 of microRNA may be a prognostic factor in lung cancer. Genetic variation in microRNA precursors could influence the processing and expression of microRNAs, which could affect the prognosis of lung cancer. We aimed to investigate the impact of single nucleotide polymorphisms (SNPs) of pri-let-7 on the prognosis of non-small cell lung cancer (NSCLC). Method: A total of 761 patients with surgically resected NSCLC were included. Four SNPs (pri-let-7a-2 rs1143770 and rs629367, pri-let-7a-1 rs10739971, and pri-let-7f-2 rs17276588) were genotyped using sequenom mass spectrometry-based genotyping assay. Overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier method and Cox proportional hazards model. Results: Of the 4 SNPs evaluated, the rs1143770C. >. T was found to be significantly associated with OS and DFS. The rs1143770 CT or TT genotype exhibited a significantly better OS and DFS compared with the rs1143770 CC genotype (adjusted hazard ratio for OS = 0.67, confidence interval, 0.49-0.91, P= 0.01 and adjusted hazard ratio for DFS = 0.74, confidence interval, 0.58-0.95, P= 0.02). Conclusion: This observation indicates that pri-let-7a-2 rs1143770C. >. T may have a prognostic impact on surgically resected NSCLC.

KW - Let-7

KW - Lung cancer

KW - MicroRNA

KW - Risk factor

KW - SNP

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U2 - 10.1016/j.gene.2015.11.036

DO - 10.1016/j.gene.2015.11.036

M3 - Article

C2 - 26625972

AN - SCOPUS:84952864169

SN - 0378-1119

VL - 577

SP - 148

EP - 152

JO - Gene

JF - Gene

IS - 2

ER -

The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer

Abstract

Keywords

UN SDGs

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