The prognostic role of preoperative serum albumin/globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy

Jae Wook Chung; Dong Jin Park; So Young Chun; Seock Hwan Choi; Jun Nyung Lee; Bum Soo Kim; Hyun Tae Kim; Tae Hwan Kim; Eun Sang Yoo; Seok Soo Byun; Eu Chang Hwang; Seok Ho Kang; Sung Hoo Hong; Jinsoo Chung; Cheol Kwak; Yong June Kim; Yun Sok Ha; Tae Gyun Kwon

doi:10.1038/s41598-020-68975-3

The prognostic role of preoperative serum albumin/globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy

Jae Wook Chung, Dong Jin Park, So Young Chun, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Tae Hwan Kim, Eun Sang Yoo, Seok Soo Byun, Eu Chang Hwang, Seok Ho Kang, Sung Hoo Hong, Jinsoo Chung, Cheol Kwak, Yong June Kim, Yun Sok Ha, Tae Gyun Kwon

Department of Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

This multi-institutional study sought to clarify the association between the preoperative serum albumin/globulin ratio (AGR) and the prognosis of renal cell carcinoma (RCC) in a large cohort. This study encompassed eight institutions and 2,970 non-metastatic RCC patients who underwent a radical or partial nephrectomy from the Korean RCC (KORCC) database. A low AGR (1,143 patients; 38.5%) was defined as a preoperative AGR of less than 1.47 and a high AGR (1,827 patients; 61.5%) was defined as that 1.47 or greater. In the low AGR group, older age, female gender, the incidence of symptom presentation when diagnosed, diabetes, and hypertension was higher than in the high AGR group. Patients with low AGRs showed more progressive tumor stages with higher Fuhrman nuclear grades (all P-values < 0.05). Patients in the low AGR group had a significantly lower overall survival rate (OS) and recurrence-free survival rate (RFS) in the Kaplan–Meier curves (all P-values < 0.05). AGR was an independent prognostic factor for predicting the OS and RFS in the multivariate analysis (all P-values < 0.05). The preoperative AGR is approachable and economical to use clinically for estimating the prognosis of RCC patients treated with surgery.

Original language	English
Article number	11999
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-68975-3
State	Published - 1 Dec 2020

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Chung, J. W., Park, D. J., Chun, S. Y., Choi, S. H., Lee, J. N., Kim, B. S., Kim, H. T., Kim, T. H., Yoo, E. S., Byun, S. S., Hwang, E. C., Kang, S. H., Hong, S. H., Chung, J., Kwak, C., Kim, Y. J., Ha, Y. S., & Kwon, T. G. (2020). The prognostic role of preoperative serum albumin/globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy. Scientific Reports, 10(1), Article 11999. https://doi.org/10.1038/s41598-020-68975-3

@article{7ac29ab08c304198866103f7505a501f,

title = "The prognostic role of preoperative serum albumin/globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy",

abstract = "This multi-institutional study sought to clarify the association between the preoperative serum albumin/globulin ratio (AGR) and the prognosis of renal cell carcinoma (RCC) in a large cohort. This study encompassed eight institutions and 2,970 non-metastatic RCC patients who underwent a radical or partial nephrectomy from the Korean RCC (KORCC) database. A low AGR (1,143 patients; 38.5%) was defined as a preoperative AGR of less than 1.47 and a high AGR (1,827 patients; 61.5%) was defined as that 1.47 or greater. In the low AGR group, older age, female gender, the incidence of symptom presentation when diagnosed, diabetes, and hypertension was higher than in the high AGR group. Patients with low AGRs showed more progressive tumor stages with higher Fuhrman nuclear grades (all P-values < 0.05). Patients in the low AGR group had a significantly lower overall survival rate (OS) and recurrence-free survival rate (RFS) in the Kaplan–Meier curves (all P-values < 0.05). AGR was an independent prognostic factor for predicting the OS and RFS in the multivariate analysis (all P-values < 0.05). The preoperative AGR is approachable and economical to use clinically for estimating the prognosis of RCC patients treated with surgery.",

author = "Chung, {Jae Wook} and Park, {Dong Jin} and Chun, {So Young} and Choi, {Seock Hwan} and Lee, {Jun Nyung} and Kim, {Bum Soo} and Kim, {Hyun Tae} and Kim, {Tae Hwan} and Yoo, {Eun Sang} and Byun, {Seok Soo} and Hwang, {Eu Chang} and Kang, {Seok Ho} and Hong, {Sung Hoo} and Jinsoo Chung and Cheol Kwak and Kim, {Yong June} and Ha, {Yun Sok} and Kwon, {Tae Gyun}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

day = "1",

doi = "10.1038/s41598-020-68975-3",

language = "English",

volume = "10",

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Chung, JW, Park, DJ, Chun, SY, Choi, SH, Lee, JN, Kim, BS, Kim, HT, Kim, TH, Yoo, ES, Byun, SS, Hwang, EC, Kang, SH, Hong, SH, Chung, J, Kwak, C, Kim, YJ, Ha, YS & Kwon, TG 2020, 'The prognostic role of preoperative serum albumin/globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy', Scientific Reports, vol. 10, no. 1, 11999. https://doi.org/10.1038/s41598-020-68975-3

TY - JOUR

T1 - The prognostic role of preoperative serum albumin/globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy

AU - Chung, Jae Wook

AU - Park, Dong Jin

AU - Chun, So Young

AU - Choi, Seock Hwan

AU - Lee, Jun Nyung

AU - Kim, Bum Soo

AU - Kim, Hyun Tae

AU - Kim, Tae Hwan

AU - Yoo, Eun Sang

AU - Byun, Seok Soo

AU - Hwang, Eu Chang

AU - Kang, Seok Ho

AU - Hong, Sung Hoo

AU - Chung, Jinsoo

AU - Kwak, Cheol

AU - Kim, Yong June

AU - Ha, Yun Sok

AU - Kwon, Tae Gyun

PY - 2020/12/1

Y1 - 2020/12/1

N2 - This multi-institutional study sought to clarify the association between the preoperative serum albumin/globulin ratio (AGR) and the prognosis of renal cell carcinoma (RCC) in a large cohort. This study encompassed eight institutions and 2,970 non-metastatic RCC patients who underwent a radical or partial nephrectomy from the Korean RCC (KORCC) database. A low AGR (1,143 patients; 38.5%) was defined as a preoperative AGR of less than 1.47 and a high AGR (1,827 patients; 61.5%) was defined as that 1.47 or greater. In the low AGR group, older age, female gender, the incidence of symptom presentation when diagnosed, diabetes, and hypertension was higher than in the high AGR group. Patients with low AGRs showed more progressive tumor stages with higher Fuhrman nuclear grades (all P-values < 0.05). Patients in the low AGR group had a significantly lower overall survival rate (OS) and recurrence-free survival rate (RFS) in the Kaplan–Meier curves (all P-values < 0.05). AGR was an independent prognostic factor for predicting the OS and RFS in the multivariate analysis (all P-values < 0.05). The preoperative AGR is approachable and economical to use clinically for estimating the prognosis of RCC patients treated with surgery.

AB - This multi-institutional study sought to clarify the association between the preoperative serum albumin/globulin ratio (AGR) and the prognosis of renal cell carcinoma (RCC) in a large cohort. This study encompassed eight institutions and 2,970 non-metastatic RCC patients who underwent a radical or partial nephrectomy from the Korean RCC (KORCC) database. A low AGR (1,143 patients; 38.5%) was defined as a preoperative AGR of less than 1.47 and a high AGR (1,827 patients; 61.5%) was defined as that 1.47 or greater. In the low AGR group, older age, female gender, the incidence of symptom presentation when diagnosed, diabetes, and hypertension was higher than in the high AGR group. Patients with low AGRs showed more progressive tumor stages with higher Fuhrman nuclear grades (all P-values < 0.05). Patients in the low AGR group had a significantly lower overall survival rate (OS) and recurrence-free survival rate (RFS) in the Kaplan–Meier curves (all P-values < 0.05). AGR was an independent prognostic factor for predicting the OS and RFS in the multivariate analysis (all P-values < 0.05). The preoperative AGR is approachable and economical to use clinically for estimating the prognosis of RCC patients treated with surgery.

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U2 - 10.1038/s41598-020-68975-3

DO - 10.1038/s41598-020-68975-3

M3 - Article

C2 - 32686760

AN - SCOPUS:85088253144

SN - 2045-2322

VL - 10

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 11999

ER -

The prognostic role of preoperative serum albumin/globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy

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