The role of nuclear PKMζ in memory maintenance

Hyoung Gon Ko; Ji il Kim; Su Eon Sim; Tae Hyun Kim; Juyoun Yoo; Sun Lim Choi; Sung Hee Baek; Won Jin Yu; Jong Bok Yoon; Todd Charlton Sacktor; Bong Kiun Kaang

doi:10.1016/j.nlm.2016.06.010

The role of nuclear PKMζ in memory maintenance

Hyoung Gon Ko, Ji il Kim, Su Eon Sim, Tae Hyun Kim, Juyoun Yoo, Sun Lim Choi, Sung Hee Baek, Won Jin Yu, Jong Bok Yoon, Todd Charlton Sacktor, Bong Kiun Kaang

Department of Dentistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.

Original language	English
Pages (from-to)	50-56
Number of pages	7
Journal	Neurobiology of Learning and Memory
Volume	135
DOIs	https://doi.org/10.1016/j.nlm.2016.06.010
State	Published - 1 Nov 2016

Keywords

CREB-binding protein
Histone acetylation
Memory maintenance
PKMζ
Translocation into nucleus

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title = "The role of nuclear PKMζ in memory maintenance",

abstract = "Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.",

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doi = "10.1016/j.nlm.2016.06.010",

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AU - Ko, Hyoung Gon

AU - Kim, Ji il

AU - Sim, Su Eon

AU - Kim, Tae Hyun

AU - Yoo, Juyoun

AU - Choi, Sun Lim

AU - Baek, Sung Hee

AU - Yu, Won Jin

AU - Yoon, Jong Bok

AU - Sacktor, Todd Charlton

AU - Kaang, Bong Kiun

PY - 2016/11/1

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N2 - Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.

AB - Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.

KW - CREB-binding protein

KW - Histone acetylation

KW - Memory maintenance

KW - PKMζ

KW - Translocation into nucleus

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JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

ER -

The role of nuclear PKMζ in memory maintenance

Abstract

Keywords

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