The role of Pin1 in the development and treatment of cancer

Sang Hyun Min; Xiao Zhen Zhou; Kun Ping Lu

doi:10.1007/s12272-016-0821-x

The role of Pin1 in the development and treatment of cancer

Sang Hyun Min, Xiao Zhen Zhou, Kun Ping Lu

Department of Innovative Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Protein phosphorylation and post-phosphorylation events regulate many cellular signaling pathways. Peptidyl-prolyl isomerase (Pin1) is the only peptidyl-prolyl cis/trans isomerase that interacts with numerous oncogenic or tumor suppressive phosphorylated proteins, causes conformational changes in target proteins, and eventually regulates the activities of such proteins. These alterations in activity play a pivotal role in tumorigenesis. Since Pin1 is overexpressed and/or activated in various types of cancers, and the dysregulation of proline-directed phosphorylation contributes to tumorigenesis, Pin1 represents an attractive target for cancer therapy. This review will describe the role of Pin1 in cancer and the current status of Pin1 inhibitor development.

Original language	English
Pages (from-to)	1609-1620
Number of pages	12
Journal	Archives of Pharmacal Research
Volume	39
Issue number	12
DOIs	https://doi.org/10.1007/s12272-016-0821-x
State	Published - 1 Dec 2016

Keywords

Cancer-driving pathways
Pin1
Pin1 inhibitor
Proline-directed phosphorylation
Prolyl isomerase
Tumorigenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12272-016-0821-x

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title = "The role of Pin1 in the development and treatment of cancer",

abstract = "Protein phosphorylation and post-phosphorylation events regulate many cellular signaling pathways. Peptidyl-prolyl isomerase (Pin1) is the only peptidyl-prolyl cis/trans isomerase that interacts with numerous oncogenic or tumor suppressive phosphorylated proteins, causes conformational changes in target proteins, and eventually regulates the activities of such proteins. These alterations in activity play a pivotal role in tumorigenesis. Since Pin1 is overexpressed and/or activated in various types of cancers, and the dysregulation of proline-directed phosphorylation contributes to tumorigenesis, Pin1 represents an attractive target for cancer therapy. This review will describe the role of Pin1 in cancer and the current status of Pin1 inhibitor development.",

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AU - Zhou, Xiao Zhen

AU - Lu, Kun Ping

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AB - Protein phosphorylation and post-phosphorylation events regulate many cellular signaling pathways. Peptidyl-prolyl isomerase (Pin1) is the only peptidyl-prolyl cis/trans isomerase that interacts with numerous oncogenic or tumor suppressive phosphorylated proteins, causes conformational changes in target proteins, and eventually regulates the activities of such proteins. These alterations in activity play a pivotal role in tumorigenesis. Since Pin1 is overexpressed and/or activated in various types of cancers, and the dysregulation of proline-directed phosphorylation contributes to tumorigenesis, Pin1 represents an attractive target for cancer therapy. This review will describe the role of Pin1 in cancer and the current status of Pin1 inhibitor development.

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The role of Pin1 in the development and treatment of cancer

Abstract

Keywords

UN SDGs

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