The role of Pin1 in the development and treatment of cancer

Sang Hyun Min; Xiao Zhen Zhou; Kun Ping Lu

doi:10.1007/s12272-016-0821-x

The role of Pin1 in the development and treatment of cancer

Sang Hyun Min
, Xiao Zhen Zhou
, Kun Ping Lu

Department of Innovative Pharmaceutical Sciences

Harvard University
Fujian Medical University

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Protein phosphorylation and post-phosphorylation events regulate many cellular signaling pathways. Peptidyl-prolyl isomerase (Pin1) is the only peptidyl-prolyl cis/trans isomerase that interacts with numerous oncogenic or tumor suppressive phosphorylated proteins, causes conformational changes in target proteins, and eventually regulates the activities of such proteins. These alterations in activity play a pivotal role in tumorigenesis. Since Pin1 is overexpressed and/or activated in various types of cancers, and the dysregulation of proline-directed phosphorylation contributes to tumorigenesis, Pin1 represents an attractive target for cancer therapy. This review will describe the role of Pin1 in cancer and the current status of Pin1 inhibitor development.

Original language	English
Pages (from-to)	1609-1620
Number of pages	12
Journal	Archives of Pharmacal Research
Volume	39
Issue number	12
DOIs	https://doi.org/10.1007/s12272-016-0821-x
State	Published - 1 Dec 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer-driving pathways
Pin1
Pin1 inhibitor
Proline-directed phosphorylation
Prolyl isomerase
Tumorigenesis

Access to Document

10.1007/s12272-016-0821-x

Cite this

@article{cb99e0a2e3e942d29fe67355726a195f,

title = "The role of Pin1 in the development and treatment of cancer",

abstract = "Protein phosphorylation and post-phosphorylation events regulate many cellular signaling pathways. Peptidyl-prolyl isomerase (Pin1) is the only peptidyl-prolyl cis/trans isomerase that interacts with numerous oncogenic or tumor suppressive phosphorylated proteins, causes conformational changes in target proteins, and eventually regulates the activities of such proteins. These alterations in activity play a pivotal role in tumorigenesis. Since Pin1 is overexpressed and/or activated in various types of cancers, and the dysregulation of proline-directed phosphorylation contributes to tumorigenesis, Pin1 represents an attractive target for cancer therapy. This review will describe the role of Pin1 in cancer and the current status of Pin1 inhibitor development.",

keywords = "Cancer-driving pathways, Pin1, Pin1 inhibitor, Proline-directed phosphorylation, Prolyl isomerase, Tumorigenesis",

author = "Min, \{Sang Hyun\} and Zhou, \{Xiao Zhen\} and Lu, \{Kun Ping\}",

note = "Publisher Copyright: {\textcopyright} 2016, The Pharmaceutical Society of Korea.",

year = "2016",

month = dec,

day = "1",

doi = "10.1007/s12272-016-0821-x",

language = "English",

volume = "39",

pages = "1609--1620",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "12",

}

TY - JOUR

T1 - The role of Pin1 in the development and treatment of cancer

AU - Min, Sang Hyun

AU - Zhou, Xiao Zhen

AU - Lu, Kun Ping

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Protein phosphorylation and post-phosphorylation events regulate many cellular signaling pathways. Peptidyl-prolyl isomerase (Pin1) is the only peptidyl-prolyl cis/trans isomerase that interacts with numerous oncogenic or tumor suppressive phosphorylated proteins, causes conformational changes in target proteins, and eventually regulates the activities of such proteins. These alterations in activity play a pivotal role in tumorigenesis. Since Pin1 is overexpressed and/or activated in various types of cancers, and the dysregulation of proline-directed phosphorylation contributes to tumorigenesis, Pin1 represents an attractive target for cancer therapy. This review will describe the role of Pin1 in cancer and the current status of Pin1 inhibitor development.

AB - Protein phosphorylation and post-phosphorylation events regulate many cellular signaling pathways. Peptidyl-prolyl isomerase (Pin1) is the only peptidyl-prolyl cis/trans isomerase that interacts with numerous oncogenic or tumor suppressive phosphorylated proteins, causes conformational changes in target proteins, and eventually regulates the activities of such proteins. These alterations in activity play a pivotal role in tumorigenesis. Since Pin1 is overexpressed and/or activated in various types of cancers, and the dysregulation of proline-directed phosphorylation contributes to tumorigenesis, Pin1 represents an attractive target for cancer therapy. This review will describe the role of Pin1 in cancer and the current status of Pin1 inhibitor development.

KW - Cancer-driving pathways

KW - Pin1

KW - Pin1 inhibitor

KW - Proline-directed phosphorylation

KW - Prolyl isomerase

KW - Tumorigenesis

UR - https://www.scopus.com/pages/publications/84984639999

U2 - 10.1007/s12272-016-0821-x

DO - 10.1007/s12272-016-0821-x

M3 - Review article

C2 - 27572155

AN - SCOPUS:84984639999

SN - 0253-6269

VL - 39

SP - 1609

EP - 1620

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 12

ER -

The role of Pin1 in the development and treatment of cancer

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this